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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-2-4
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pubmed:abstractText |
Osteoarthritic (OA) cartilage degeneration and cartilage destruction in rheumatoid arthritis depends significantly on enzymatic degradation of cartilage proteoglycan aggrecan. A member of the ADAMTS family of proteases, ADAMTS-1 was described to have "aggrecanase" activity. We investigated the quantitative expression and distribution of ADAMTS-1 in healthy and OA cartilage and in cultured articular chondrocytes with and without stimulation by interleukin 1beta (IL-1beta) and insulin-like growth factor-I (IGF-I).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0315-162X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14760803-ADAM Proteins,
pubmed-meshheading:14760803-Adult,
pubmed-meshheading:14760803-Aged,
pubmed-meshheading:14760803-Aged, 80 and over,
pubmed-meshheading:14760803-Cells, Cultured,
pubmed-meshheading:14760803-Chondrocytes,
pubmed-meshheading:14760803-Disintegrins,
pubmed-meshheading:14760803-Down-Regulation,
pubmed-meshheading:14760803-Gene Expression,
pubmed-meshheading:14760803-Humans,
pubmed-meshheading:14760803-Insulin-Like Growth Factor I,
pubmed-meshheading:14760803-Interleukin-1,
pubmed-meshheading:14760803-Metalloendopeptidases,
pubmed-meshheading:14760803-Middle Aged,
pubmed-meshheading:14760803-Osteoarthritis,
pubmed-meshheading:14760803-RNA, Messenger,
pubmed-meshheading:14760803-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14760803-Taq Polymerase
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pubmed:year |
2004
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pubmed:articleTitle |
ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta.
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pubmed:affiliation |
Cartilage Research Unit, Department of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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