Source:http://linkedlifedata.com/resource/pubmed/id/14616008
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
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| pubmed:dateCreated |
2003-11-17
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| pubmed:abstractText |
A series of theoretical calculations is presented to quantify the gain in LC separation efficiency that can be expected if the traditionally used packed bed columns were replaced by columns with a perfectly ordered flow-through pore network. It is shown that a perfectly ordered 2-D array of porous cylindrical pillars could yield reduced plate heights as small as h = 0.65 (for k' ' = 0.75) to h = 0.85 (for k' ' = 2) and separation impedances as small as E = 200 (for k' ' = 0.75) to E = 300 (for k' ' = 2) without having to compromise on the porosity (epsilon = 0.4) and the retention capacity of the packed bed of spheres. Fitting the calculated van Deemter plots with Knox's equation especially shows a strong decrease of the A-term contribution, hence confirming that the improved column performance indeed stems from the increased homogeneity of the packing. The presented results, hence, provide a clear quantitative support for Knox's recent argumentation that the use of more uniform beds could greatly enhance the efficiency of pressure-driven LC.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0003-2700
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
75
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6244-50
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| pubmed:year |
2003
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| pubmed:articleTitle |
Advantages of perfectly ordered 2-D porous pillar arrays over packed bed columns for LC separations: a theoretical analysis.
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| pubmed:affiliation |
Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050 Brussels, Belgium. pgzil@vub.ac.be
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| pubmed:publicationType |
Journal Article
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