Source:http://linkedlifedata.com/resource/pubmed/id/14568939
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2003-10-21
|
| pubmed:abstractText |
B7-H4 is a recently identified B7 family member that negatively regulates T cell immunity by the inhibition of T cell proliferation, cytokine production, and cell cycle progression. In this study, we report that the genomic DNA of human B7-H4 is mapped on chromosome 1 comprised of six exons and five introns spanning 66 kb, of which exon 6 is used for alternative splicing to generate two different transcripts. Similar B7-H4 structure is also found in mouse genomic DNA in chromosome 3. A human B7-H4 pseudogene is identified in chromosome 20p11.1 with a single exon and two stop codons in the coding region. Immunohistochemistry analysis using B7-H4-specific mAb demonstrates that B7-H4 is not expressed on the majority of normal human tissues. In contrast, up to 85% (22 of 26) of ovarian cancer and 31% (5 of 16) of lung cancer tissues constitutively express B7-H4. Our results indicate a tight regulation of B7-H4 expression in the translational level in normal peripheral tissues and a potential role of B7-H4 in the evasion of tumor immunity.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/V-Set Domain-Containing T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/VTCN1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vtcn1 protein, mouse
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
171
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4650-4
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:14568939-Animals,
pubmed-meshheading:14568939-Antigens, CD80,
pubmed-meshheading:14568939-Cell Line, Tumor,
pubmed-meshheading:14568939-Down-Regulation,
pubmed-meshheading:14568939-Exons,
pubmed-meshheading:14568939-Female,
pubmed-meshheading:14568939-Gene Expression Profiling,
pubmed-meshheading:14568939-Gene Order,
pubmed-meshheading:14568939-Humans,
pubmed-meshheading:14568939-Introns,
pubmed-meshheading:14568939-Lung Neoplasms,
pubmed-meshheading:14568939-Mice,
pubmed-meshheading:14568939-Multigene Family,
pubmed-meshheading:14568939-Neoplasm Proteins,
pubmed-meshheading:14568939-Organ Specificity,
pubmed-meshheading:14568939-Ovarian Neoplasms,
pubmed-meshheading:14568939-Sequence Analysis, DNA,
pubmed-meshheading:14568939-Transcription, Genetic,
pubmed-meshheading:14568939-V-Set Domain-Containing T-Cell Activation Inhibitor 1
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family.
|
| pubmed:affiliation |
Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|