Linked Life Data

14518269

Source:http://linkedlifedata.com/resource/pubmed/id/14518269

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Suppl I
pubmed:dateCreated
2003-10-1
pubmed:abstractText
Oxygen radicals and nitric oxide are involved in a variety of regulative processes especially with regard to inflammation, immunoregulation and regulation of the vascular tone. The aim of our study was to investigate the effects of both these highly reactive molecules on the proliferation of human fibroblasts. We therefore cultured WI38 cells under various culture conditions like exposure to oxygen radicals and endogenously produced as well as exogenously applied nitric oxide. Exposure of WI38 to oxygen radicals led to a reduction of cell proliferation. Similarly induction of endogenous nitric oxide production by cytokines induced an inhibition in cell proliferation. Interestingly exogenously applied nitric oxide increased proliferation rates of WI38 cells. These data could point to a functional role of oxygen radicals and nitric oxide in the regulation of fibroblast growth.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0942-2854
pubmed:author
pubmed:issnType
Print
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-7
pubmed:dateRevised
2008-2-20
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
[Nitrogen monoxide and oxygen radicals work contrarily on proliferation behavior of human fibroblasts].
pubmed:affiliation
Chirurgische Klinik I, Universität Ulm, Steinhövelstr. 9, 89075 Ulm.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract