Linked Life Data

1427663

Source:http://linkedlifedata.com/resource/pubmed/id/1427663

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-12-1
pubmed:abstractText
Hepatocyte growth factor, a potent hepatocyte mitogen in vitro, appears to trigger hepatocyte regeneration after partial hepatectomy and after acute liver cell necrosis. Transforming growth factor-alpha and transforming growth factor-beta 1 may also be involved in the control of liver regeneration. In this study we assessed possible roles of hepatocyte growth factor, transforming growth factor-alpha and transforming growth factor-beta 1 on liver cell proliferation in vivo, using a model of choline deficiency that is associated with liver cell necrosis and a model of a hypolipidemic agent (4-chloro-6-(2,3 xylidino)-2-pyrimidinylthio (N-beta-hydroxyethyl) acetamide) without liver necrosis. Male F344 rats were fed a choline-deficient diet or 0.16% 4-chloro-6-(2,3 xylidino)-2-pyrimidinylthio (N-beta-hydroxyethyl) acetamide diet for 6 and 4 wk, respectively. Rats were killed periodically, and the expression of hepatocyte growth factor messenger RNA in the liver, lung and kidney was determined by Northern-blot analysis. The levels of transforming growth factor-alpha and transforming growth factor-beta 1 messenger RNAs in the liver were also determined. Feeding a choline-deficient diet for 1 to 6 wk led to gradual increases in the levels of hepatocyte growth factor, transforming growth factor-alpha and transforming growth factor-beta 1 messenger RNAs in the liver. Feeding a 4-chloro-6-(2,3 xylidino)-2-pyrimidinylthio (N-beta-hydroxyethyl) acetamide diet for 3 days and 2 wk induced marked enhancement of liver cell proliferation as judged by hepatocyte 5-bromo-2-deoxyuridine incorporation.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0270-9139
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1241-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:1427663-Animals, pubmed-meshheading:1427663-Base Sequence, pubmed-meshheading:1427663-Cell Division, pubmed-meshheading:1427663-Choline Deficiency, pubmed-meshheading:1427663-DNA Probes, pubmed-meshheading:1427663-Gene Expression, pubmed-meshheading:1427663-Hepatocyte Growth Factor, pubmed-meshheading:1427663-Hypolipidemic Agents, pubmed-meshheading:1427663-Kidney, pubmed-meshheading:1427663-Liver, pubmed-meshheading:1427663-Lung, pubmed-meshheading:1427663-Male, pubmed-meshheading:1427663-Molecular Sequence Data, pubmed-meshheading:1427663-Organ Size, pubmed-meshheading:1427663-Pyrimidines, pubmed-meshheading:1427663-RNA, Messenger, pubmed-meshheading:1427663-Rats, pubmed-meshheading:1427663-Rats, Inbred F344, pubmed-meshheading:1427663-Transforming Growth Factor alpha, pubmed-meshheading:1427663-Transforming Growth Factor beta
pubmed:year
1992
pubmed:articleTitle
Differential expression of hepatocyte growth factor, transforming growth factor-alpha and transforming growth factor-beta 1 messenger RNAs in two experimental models of liver cell proliferation.
pubmed:affiliation
Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15261.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.