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rdf:type |
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lifeskim:mentions |
umls-concept:C0006024,
umls-concept:C0033684,
umls-concept:C0035414,
umls-concept:C0085424,
umls-concept:C0318798,
umls-concept:C0332597,
umls-concept:C1335439,
umls-concept:C1514562,
umls-concept:C1710052,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
11
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pubmed:dateCreated |
1992-11-18
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pubmed:databankReference |
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pubmed:abstractText |
We report the sequence of a Borna disease virus clone (pBDV-40) that encodes a 40-kDa protein (p40) found in the nuclei of infected cells. Comparative sequence analysis indicates that p40 is distantly similar to two different regions in the L-polymerase proteins encoded by paramyxoviruses and rhabdoviruses. The p40 sequence similarity indicates a previously undetected duplication in these viral polymerases. Phylogenetic reconstruction suggests that the gene that encodes p40 last shared a common ancestor with these viral polymerase genes prior to the duplication event. These findings support the hypothesis that Borna disease virus is a negative-strand RNA virus and suggest that p40 is involved in transcription and/or replication. The discovery of a duplication within the polymerase proteins of paramyxoviruses and rhabdoviruses has profound implications for the mapping of enzymatic activities within these multifunctional proteins.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-1370546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-1412695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-1663570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-1693432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-1895063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2022964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2038820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2053282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2196557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2231712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2238474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2244211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2439916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2549720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2555175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2668735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-2901550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-3118049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-3291115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-3313277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-3447013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-3922055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-3931604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-4413342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-6100188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-6207484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-6431612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-823012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1404604-8437242
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6572-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1404604-Amino Acid Sequence,
pubmed-meshheading:1404604-Base Sequence,
pubmed-meshheading:1404604-Biological Evolution,
pubmed-meshheading:1404604-Borna disease virus,
pubmed-meshheading:1404604-Cell-Free System,
pubmed-meshheading:1404604-Chromosome Mapping,
pubmed-meshheading:1404604-Cloning, Molecular,
pubmed-meshheading:1404604-Molecular Sequence Data,
pubmed-meshheading:1404604-Open Reading Frames,
pubmed-meshheading:1404604-Paramyxoviridae,
pubmed-meshheading:1404604-Protein Biosynthesis,
pubmed-meshheading:1404604-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1404604-Rhabdoviridae,
pubmed-meshheading:1404604-Sequence Homology, Amino Acid,
pubmed-meshheading:1404604-Transcription, Genetic,
pubmed-meshheading:1404604-Viral Proteins
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pubmed:year |
1992
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pubmed:articleTitle |
Sequence similarity between Borna disease virus p40 and a duplicated domain within the paramyxovirus and rhabdovirus polymerase proteins.
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pubmed:affiliation |
Department of Ecology and Evolutionary Biology, University of California, Irvine 92717.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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