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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4-5
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pubmed:dateCreated |
2003-8-1
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pubmed:abstractText |
In this mini review we summarize recent studies from our laboratory, which show the involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and caspase-3 activation. Cells exposed to mild, transient, heat or oxidative stress acquire capacity to exclude intracellular 4-HNE at a faster rate by inducing hGST5.8 which conjugate 4-HNE to GSH, and RLIP76 which mediates the ATP-dependent transport of the GSH-conjugate of 4-HNE. The cells preconditioned with mild transient stress acquire resistance to H(2)O(2) and 4-HNE induced apoptosis by excluding intracellular 4-HNE at an accelerated pace. Furthermore, a decrease in intracellular concentration of 4-HNE achieved by transfecting cells with mGSTA4-4 or hGSTA4-4 results in a faster growth rate. These studies strongly suggest a role of 4-HNE in stress mediated signaling.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-hydroxy-2-nonenal,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Aldehydes,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RALBP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1
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pubmed:status |
MEDLINE
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pubmed:issn |
0098-2997
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-30
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12893000-ATP-Binding Cassette Transporters,
pubmed-meshheading:12893000-Aldehydes,
pubmed-meshheading:12893000-Animals,
pubmed-meshheading:12893000-Apoptosis,
pubmed-meshheading:12893000-Carrier Proteins,
pubmed-meshheading:12893000-Caspase 3,
pubmed-meshheading:12893000-Caspases,
pubmed-meshheading:12893000-GTPase-Activating Proteins,
pubmed-meshheading:12893000-Glutathione Transferase,
pubmed-meshheading:12893000-Hydrogen Peroxide,
pubmed-meshheading:12893000-Lipid Peroxidation,
pubmed-meshheading:12893000-Mice,
pubmed-meshheading:12893000-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12893000-Signal Transduction,
pubmed-meshheading:12893000-Transcription Factor AP-1
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pubmed:articleTitle |
Role of 4-hydroxynonenal in stress-mediated apoptosis signaling.
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pubmed:affiliation |
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 551 Basic Science Building, Galveston, TX 77555-0647, USA. ycawasth@utmb.ca
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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