| pubmed-article:12865414 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12865414 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:12865414 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12865414 | lifeskim:mentions | umls-concept:C0026896 | lld:lifeskim |
| pubmed-article:12865414 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:12865414 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:12865414 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:12865414 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:12865414 | lifeskim:mentions | umls-concept:C0076533 | lld:lifeskim |
| pubmed-article:12865414 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12865414 | pubmed:dateCreated | 2003-7-16 | lld:pubmed |
| pubmed-article:12865414 | pubmed:abstractText | Serum anti-T cell receptor (TCR) Ab's are involved in immune regulation directed against pathogenic T cells in experimental models of autoimmune diseases. Our identification of a dominant T cell population expressing the Vbeta5.1 TCR gene (TCRBV5-1), which is responsible for the production of pathogenic anti-acetylcholine receptor (AChR) autoantibodies in HLA-DR3 patients with early-onset myasthenia gravis (EOMG), prompted us to explore the occurrence, reactivity, and regulatory role of anti-TCR Ab's in EOMG patients and disease controls with clearly defined other autoantibodies. In the absence of prior vaccination against the TCR, EOMG patients had elevated anti-Vbeta5.1 Ab's of the IgG class. This increase was restricted largely to EOMG cases with HLA-DR3 and with less severe disease, and it predicted clinical improvement in follow-up studies. EOMG patient sera containing anti-TCR Ab's bound specifically the native TCR on intact Vbeta5.1-expressing cells and specifically inhibited the proliferation and IFN-gamma production of purified Vbeta5.1-expressing cells to alloantigens in mixed lymphocyte reaction and the proliferation of a Vbeta5.1-expressing T cell clone to an AChR peptide, indicating a regulatory function for these Ab's. This evidence of spontaneously active anti-Vbeta5.1 Ab's in EOMG patients suggests dynamic protective immune regulation directed against the excess of pathogenic Vbeta5.1-expressing T cells. Though not sufficient to prevent a chronic, exacerbated autoimmune process, it might be boosted using a TCR peptide as vaccine. | lld:pubmed |
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| pubmed-article:12865414 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12865414 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12865414 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12865414 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12865414 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12865414 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12865414 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:12865414 | pubmed:author | pubmed-author:ZhangWeiW | lld:pubmed |
| pubmed-article:12865414 | pubmed:author | pubmed-author:AissaouiAbder... | lld:pubmed |
| pubmed-article:12865414 | pubmed:author | pubmed-author:Caillat-Zucma... | lld:pubmed |
| pubmed-article:12865414 | pubmed:author | pubmed-author:MichelOlivier... | lld:pubmed |
| pubmed-article:12865414 | pubmed:author | pubmed-author:JambouFlorenc... | lld:pubmed |
| pubmed-article:12865414 | pubmed:author | pubmed-author:MenestrierMon... | lld:pubmed |
| pubmed-article:12865414 | pubmed:author | pubmed-author:Klingel-Schmi... | lld:pubmed |
| pubmed-article:12865414 | pubmed:author | pubmed-author:LandemarreLud... | lld:pubmed |
| pubmed-article:12865414 | pubmed:author | pubmed-author:Berrih-AkninS... | lld:pubmed |
| pubmed-article:12865414 | pubmed:author | pubmed-author:Cohen-Kaminsk... | lld:pubmed |
| pubmed-article:12865414 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12865414 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:12865414 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12865414 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12865414 | pubmed:pagination | 265-74 | lld:pubmed |
| pubmed-article:12865414 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12865414 | pubmed:meshHeading | pubmed-meshheading:12865414... | lld:pubmed |
| pubmed-article:12865414 | pubmed:meshHeading | pubmed-meshheading:12865414... | lld:pubmed |
| pubmed-article:12865414 | pubmed:meshHeading | pubmed-meshheading:12865414... | lld:pubmed |
