Linked Life Data

12743452

Source:http://linkedlifedata.com/resource/pubmed/id/12743452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-5-13
pubmed:abstractText
The amount of inflammatory cytokines is a major determinant for the development of sepsis in very-low-birth-weight (VLBW) neonates. We investigated whether variants of tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-4 receptor alpha-chain, IL-6 and IL-10 genes, associated with altered cytokine production, might influence the risk and complications of sepsis in VLBW infants. We determined the presence of these genetic variants in dried blood samples of 33 septic, 35 infected and 35 healthy VLBW neonates by PCR and RFLP methods and analyzed their association with the risk and complications of sepsis. The frequencies of genetic variants did not differ in uninfected and in infected infants with or without sepsis. Moreover, none of the studied complications was associated with carrier state of any of genetic variants. Four of the 5 septic neonates with disseminated intravascular coagulation, however, carried simultaneously the variants of IL-1 beta and IL-10 genes. We concluded that these genetic polymorphisms do not influence the risk and course of sepsis in VLBW neonates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0006-3126
pubmed:author
pubmed:copyrightInfo
Copyright 2003 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12743452-Alleles, pubmed-meshheading:12743452-Genetic Predisposition to Disease, pubmed-meshheading:12743452-Genetic Variation, pubmed-meshheading:12743452-Genotype, pubmed-meshheading:12743452-Humans, pubmed-meshheading:12743452-Infant, Low Birth Weight, pubmed-meshheading:12743452-Infant, Newborn, pubmed-meshheading:12743452-Interleukin-1, pubmed-meshheading:12743452-Interleukin-10, pubmed-meshheading:12743452-Interleukin-6, pubmed-meshheading:12743452-Interleukins, pubmed-meshheading:12743452-Mutation, pubmed-meshheading:12743452-Polymerase Chain Reaction, pubmed-meshheading:12743452-Polymorphism, Restriction Fragment Length, pubmed-meshheading:12743452-Receptors, Interleukin-4, pubmed-meshheading:12743452-Sepsis, pubmed-meshheading:12743452-Tumor Necrosis Factor-alpha
pubmed:year
2003
pubmed:articleTitle
Genetic variants of TNF-[FC12]a, IL-1beta, IL-4 receptor [FC12]a-chain, IL-6 and IL-10 genes are not risk factors for sepsis in low-birth-weight infants.
pubmed:affiliation
Research Laboratory of Pediatrics and Nephrology, Semmelweis University, Budapest, Hungary. treand@freemail.hu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't