Linked Life Data

12727137

Source:http://linkedlifedata.com/resource/pubmed/id/12727137

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-5-2
pubmed:abstractText
In mice and humans, the size of the peripheral lymphocyte pool remains relatively constant throughout adult life, in the absence of disease. Among the factors that influence the survival and homeostasis of T cells, external stimuli such as infections have long been considered to be of primary importance. However, emerging data indicate that internal stimuli, including self-peptide (presented in association with major-histocompatibility-complex molecules) and cytokines, might also control the size and composition of T-cell pools. Recent evidence suggests that cytotoxic-T-lymphocyte-associated antigen 4, an immune attenuator, contributes significantly to the homeostatic control of T-helper-cell proliferation through mechanisms that are both intrinsic and extrinsic to the T cell.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1471-4914
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-5
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
CTLA-4, T helper lymphocytes and dendritic cells: an internal perspective of T-cell homeostasis.
pubmed:affiliation
Department of Experimental Medicine, Via del Giochetto, University of Perugia, 06126 Perugia, Italy. ugrohmann@tin.it
pubmed:publicationType
Journal Article, Review