| pubmed-article:12717440 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12717440 | lifeskim:mentions | umls-concept:C0076930 | lld:lifeskim |
| pubmed-article:12717440 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12717440 | lifeskim:mentions | umls-concept:C0243127 | lld:lifeskim |
| pubmed-article:12717440 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12717440 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12717440 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12717440 | lifeskim:mentions | umls-concept:C0443331 | lld:lifeskim |
| pubmed-article:12717440 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12717440 | pubmed:dateCreated | 2003-5-1 | lld:pubmed |
| pubmed-article:12717440 | pubmed:abstractText | Endocytosis of cell surface receptors is an important regulatory event in signal transduction. The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are rapidly internalized and then downregulated in a ubiquitin-dependent manner. Here we demonstrate that TGF-beta receptors internalize into both caveolin- and EEA1-positive vesicles and reside in both lipid raft and non-raft membrane domains. Clathrin-dependent internalization into the EEA1-positive endosome, where the Smad2 anchor SARA is enriched, promotes TGF-beta signalling. In contrast, the lipid raft-caveolar internalization pathway contains the Smad7-Smurf2 bound receptor and is required for rapid receptor turnover. Thus, segregation of TGF-beta receptors into distinct endocytic compartments regulates Smad activation and receptor turnover. | lld:pubmed |
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| pubmed-article:12717440 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12717440 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12717440 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12717440 | pubmed:month | May | lld:pubmed |
| pubmed-article:12717440 | pubmed:issn | 1465-7392 | lld:pubmed |
| pubmed-article:12717440 | pubmed:author | pubmed-author:WranaJeffrey... | lld:pubmed |
| pubmed-article:12717440 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:12717440 | pubmed:author | pubmed-author:Le... | lld:pubmed |
| pubmed-article:12717440 | pubmed:author | pubmed-author:GoodfellowAnn... | lld:pubmed |
| pubmed-article:12717440 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12717440 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:12717440 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12717440 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12717440 | pubmed:pagination | 410-21 | lld:pubmed |
| pubmed-article:12717440 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12717440 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12717440 | pubmed:articleTitle | Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. | lld:pubmed |
| pubmed-article:12717440 | pubmed:affiliation | Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada. | lld:pubmed |
| pubmed-article:12717440 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12717440 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12717440 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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