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pubmed-article:12686527pubmed:abstractTextMultiple endocrine neoplasia type 2 (MEN 2) is caused by RET proto-oncogene mutations and has a strong penetrance for medullary thyroid carcinoma (MTC). Subtypes are defined by the presence or absence of pheochromocytomas, hyperparathyroidism, and characteristic clinical stigmas. We hypothesize that specific RET mutations correlate with the MEN 2 phenotype and aggressiveness of MTC.lld:pubmed
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pubmed-article:12686527pubmed:pagination409-16; discussion 416lld:pubmed
pubmed-article:12686527pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:12686527pubmed:articleTitleMultiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship.lld:pubmed
pubmed-article:12686527pubmed:affiliationDepartment of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.lld:pubmed
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