| pubmed-article:12364389 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12364389 | lifeskim:mentions | umls-concept:C0003847 | lld:lifeskim |
| pubmed-article:12364389 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:12364389 | lifeskim:mentions | umls-concept:C0007018 | lld:lifeskim |
| pubmed-article:12364389 | lifeskim:mentions | umls-concept:C0949653 | lld:lifeskim |
| pubmed-article:12364389 | lifeskim:mentions | umls-concept:C0700124 | lld:lifeskim |
| pubmed-article:12364389 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:12364389 | lifeskim:mentions | umls-concept:C1999177 | lld:lifeskim |
| pubmed-article:12364389 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:12364389 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12364389 | pubmed:dateCreated | 2002-10-4 | lld:pubmed |
| pubmed-article:12364389 | pubmed:abstractText | Carbon monoxide (CO) is generated endogenously by the enzyme heme oxygenase. Although CO is a known vasodilator, cellular signaling mechanisms are poorly understood and are a source of controversy. The goal of the present study was to investigate mechanisms of CO dilation in porcine cerebral arterioles. Data indicate that exogenous or endogenously produced CO is a potent activator of large-conductance Ca2+-activated K+ (K(Ca)) channels and Ca2+ spark-induced transient K(Ca) currents in arteriole smooth muscle cells. In contrast, CO is a relatively poor activator of Ca2+ sparks. To understand the apparent discrepancy between potent effects on transient K(Ca) currents and weak effects on Ca2+ sparks, regulation of the coupling relationship between these events by CO was investigated. CO increased the percentage of Ca2+ sparks that activated a transient K(Ca) current (ie, the coupling ratio) from approximately 62% in the control condition to 100% and elevated the slope of the amplitude correlation between these events approximately 2.6-fold, indicating that Ca2+ sparks induced larger amplitude transient K(Ca) currents in the presence of CO. This signaling pathway for CO is physiologically relevant because ryanodine, a ryanodine-sensitive Ca2+ release channel blocker that inhibits Ca2+ sparks, abolished CO dilation of pial arterioles in vivo. Thus, CO dilates cerebral arterioles by priming K(Ca) channels for activation by Ca2+ sparks. This study presents a novel dilatory signaling pathway for CO in the cerebral circulation and appears to be the first demonstration [corrected] of a vasodilator that acts by increasing the effective coupling of Ca2+ sparks to K(Ca) channels. | lld:pubmed |
| pubmed-article:12364389 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12364389 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12364389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12364389 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12364389 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12364389 | pubmed:issn | 1524-4571 | lld:pubmed |
| pubmed-article:12364389 | pubmed:author | pubmed-author:LefflerCharle... | lld:pubmed |
| pubmed-article:12364389 | pubmed:author | pubmed-author:CheranovSergu... | lld:pubmed |
| pubmed-article:12364389 | pubmed:author | pubmed-author:JaggarJonatha... | lld:pubmed |
| pubmed-article:12364389 | pubmed:author | pubmed-author:TcheranovaDil... | lld:pubmed |
| pubmed-article:12364389 | pubmed:author | pubmed-author:EShuyuS | lld:pubmed |
| pubmed-article:12364389 | pubmed:author | pubmed-author:ChengXiaoyang... | lld:pubmed |
| pubmed-article:12364389 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12364389 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:12364389 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:12364389 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12364389 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12364389 | pubmed:pagination | 610-7 | lld:pubmed |
| pubmed-article:12364389 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:meshHeading | pubmed-meshheading:12364389... | lld:pubmed |
| pubmed-article:12364389 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12364389 | pubmed:articleTitle | Carbon monoxide dilates cerebral arterioles by enhancing the coupling of Ca2+ sparks to Ca2+-activated K+ channels. | lld:pubmed |
| pubmed-article:12364389 | pubmed:affiliation | Department of Physiology, University of Tennessee Health Science Center, Memphis 38163, USA. jjaggar@physio1.utmem.edu | lld:pubmed |
| pubmed-article:12364389 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12364389 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12364389 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12364389 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12364389 | lld:pubmed |
