pubmed-article:12352619 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12352619 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
pubmed-article:12352619 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
pubmed-article:12352619 | lifeskim:mentions | umls-concept:C0337810 | lld:lifeskim |
pubmed-article:12352619 | lifeskim:mentions | umls-concept:C1704829 | lld:lifeskim |
pubmed-article:12352619 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
pubmed-article:12352619 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
pubmed-article:12352619 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
pubmed-article:12352619 | lifeskim:mentions | umls-concept:C0205202 | lld:lifeskim |
pubmed-article:12352619 | pubmed:issue | 13 | lld:pubmed |
pubmed-article:12352619 | pubmed:dateCreated | 2002-9-27 | lld:pubmed |
pubmed-article:12352619 | pubmed:abstractText | Interleukin-6 (IL-6) is a multifunctional cytokine playing a crucial role in inflammation and tissue injury. A role for this molecule in neurodegeneration and Alzheimer's disease (AD) has been proposed. The aim of this study was to evaluate the association between a common polymorphism of the IL-6 gene promoter and AD in the Italian population. We found that the frequency of the GG genotype was significantly higher in AD patients than controls on both univariate ( rho< 0.0001) and multivariate analysis ( rho< 0.0001). In contrast, the CC genotype seems to be associated with a reduced risk of disease ( rho< 0.0001). Our data indicate that the IL-6 gene polymorphism is associated with AD in Italians and confirm that IL-6 is crucial in the pathophysiology of neurodegenerative disorders. | lld:pubmed |
pubmed-article:12352619 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12352619 | pubmed:language | eng | lld:pubmed |
pubmed-article:12352619 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12352619 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:12352619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12352619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12352619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12352619 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12352619 | pubmed:month | Sep | lld:pubmed |
pubmed-article:12352619 | pubmed:issn | 0959-4965 | lld:pubmed |
pubmed-article:12352619 | pubmed:author | pubmed-author:BernabeiRober... | lld:pubmed |
pubmed-article:12352619 | pubmed:author | pubmed-author:GaetaniEleono... | lld:pubmed |
pubmed-article:12352619 | pubmed:author | pubmed-author:FlexAndreaA | lld:pubmed |
pubmed-article:12352619 | pubmed:author | pubmed-author:PolaPaoloP | lld:pubmed |
pubmed-article:12352619 | pubmed:author | pubmed-author:PolaRobertoR | lld:pubmed |
pubmed-article:12352619 | pubmed:author | pubmed-author:GerardinoLaur... | lld:pubmed |
pubmed-article:12352619 | pubmed:author | pubmed-author:LagoAntonio... | lld:pubmed |
pubmed-article:12352619 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:12352619 | pubmed:day | 16 | lld:pubmed |
pubmed-article:12352619 | pubmed:volume | 13 | lld:pubmed |
pubmed-article:12352619 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12352619 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12352619 | pubmed:pagination | 1645-7 | lld:pubmed |
pubmed-article:12352619 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:12352619 | pubmed:year | 2002 | lld:pubmed |
pubmed-article:12352619 | pubmed:articleTitle | The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with Alzheimer's disease in an Italian population [corrected]. | lld:pubmed |
pubmed-article:12352619 | pubmed:affiliation | Laboratory of Vascular Biology and Genetics, A Gemelli University Hospital, Università Cattolica del Sacro Cuore School of Medicine, L.go A. Gemelli 8, 00168 Rome, Italy. | lld:pubmed |
pubmed-article:12352619 | pubmed:publicationType | Journal Article | lld:pubmed |
entrez-gene:3569 | entrezgene:pubmed | pubmed-article:12352619 | lld:entrezgene |
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