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pubmed-article:12188925pubmed:abstractTextThe intrarenal natriuretic hormone dopamine (DA) is metabolised by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO). Inhibition of COMT, as opposed to MAO, results in a potent natriuretic response in the rat. The present study in anaesthetized homozygous and heterozygous COMT gene deleted mice attempted to further elucidate the importance of COMT in renal DA and sodium handling. After acute intravenous isotonic sodium loading, renal function was followed.lld:pubmed
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pubmed-article:12188925pubmed:articleTitleReduced natriuretic response to acute sodium loading in COMT gene deleted mice.lld:pubmed
pubmed-article:12188925pubmed:affiliationDept of Medical Cell Biology, University of Uppsala, Biomedical Centre, Uppsala, Sweden. cecilia.odlind@physiology.uu.selld:pubmed
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