| pubmed-article:12067909 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12067909 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12067909 | lifeskim:mentions | umls-concept:C0023823 | lld:lifeskim |
| pubmed-article:12067909 | lifeskim:mentions | umls-concept:C0003593 | lld:lifeskim |
| pubmed-article:12067909 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:12067909 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:12067909 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:12067909 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12067909 | pubmed:dateCreated | 2002-6-17 | lld:pubmed |
| pubmed-article:12067909 | pubmed:abstractText | The low density lipoprotein (LDL) receptor is well known for its role in mediating the removal of apolipoprotein B (apoB)-containing lipoproteins from plasma. Results from in vitro studies in primary mouse hepatocytes suggest that the LDL receptor may also have a role in the regulation of very low density lipoprotein (VLDL) production. We conducted in vivo experiments using LDLR-/-, LDLR+/-, and wild-type mice (LDLR indicates LDL receptor gene) in which the production rate of VLDL was measured after the injection of [35S]methionine and the lipase inhibitor Triton WR1339. Despite the fact that LDLR-/- mice had a 3.7-fold higher total cholesterol level and a 2.1-fold higher triglyceride level than those of the wild-type mice, there was no difference in the production rate of VLDL triglyceride or VLDL apoB between these groups of animals. Experiments were also conducted in apobec1-/- mice, which make only apoB-100, the form of apoB that binds to the LDL receptor. Interestingly, the apobec1-/- mice had a significantly higher production rate of apoB than did the wild-type mice. However, despite significant differences in total cholesterol and triglyceride levels, there was no difference in the production rate of total or VLDL triglyceride or VLDL apoB between LDLR-/- and LDLR+/- mice on an apobec1-/- background. These results indicate that the LDL receptor has no effect on the production rate of VLDL triglyceride or apoB in vivo in mice. | lld:pubmed |
| pubmed-article:12067909 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12067909 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067909 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12067909 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12067909 | pubmed:issn | 1524-4636 | lld:pubmed |
| pubmed-article:12067909 | pubmed:author | pubmed-author:RaderDaniel... | lld:pubmed |
| pubmed-article:12067909 | pubmed:author | pubmed-author:MaugeaisCyril... | lld:pubmed |
| pubmed-article:12067909 | pubmed:author | pubmed-author:MillarJohn... | lld:pubmed |
| pubmed-article:12067909 | pubmed:author | pubmed-author:FukiIlia VIV | lld:pubmed |
| pubmed-article:12067909 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12067909 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12067909 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12067909 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12067909 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12067909 | pubmed:pagination | 989-94 | lld:pubmed |
| pubmed-article:12067909 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12067909 | pubmed:meshHeading | pubmed-meshheading:12067909... | lld:pubmed |
| pubmed-article:12067909 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12067909 | pubmed:articleTitle | Normal production rate of apolipoprotein B in LDL receptor-deficient mice. | lld:pubmed |
| pubmed-article:12067909 | pubmed:affiliation | Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA. jsmillar@mail.med.upenn.edu | lld:pubmed |
| pubmed-article:12067909 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12067909 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12067909 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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