Source:http://linkedlifedata.com/resource/pubmed/id/11924833
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2002-4-1
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pubmed:abstractText |
Both clinical as well as experimental data support the concept of psoriasis being a T-cell-mediated immune disease possibly triggered by bacterial superantigens. Further analysis of its pathogenesis was facilitated by the generation of a xenogeneic transplantation model in which skin from psoriatic patients is grafted onto SCID mice lacking functional B and T cells. Applying this model it was demonstrated that psoriasis can be triggered by bacterial superantigens; this process depends on the presence of immunocytes. Mutated variants of the respective superantigens exhibiting no measurable affinity to HLA class II molecules can function as competitive inhibitors in vivo.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1087-0024
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-2
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11924833-Animals,
pubmed-meshheading:11924833-Antigens, Bacterial,
pubmed-meshheading:11924833-Disease Models, Animal,
pubmed-meshheading:11924833-Humans,
pubmed-meshheading:11924833-Psoriasis,
pubmed-meshheading:11924833-Skin Transplantation,
pubmed-meshheading:11924833-Superantigens,
pubmed-meshheading:11924833-Transplantation, Heterologous
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pubmed:year |
2001
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pubmed:articleTitle |
Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis.
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pubmed:affiliation |
Department of Dermatology, University of Frankfurt, Germany. Boehncke@em.uni-frankfurt.de
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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