{
  "http://linkedlifedata.com/resource/pubmed/id/11893750" : {
    "http://linkedlifedata.com/resource/pubmed/abstractText" : [ {
      "value" : "The p53 tumor suppressor gene is the most frequent target for genetic alterations in human cancers, whereas the recently discovered homologues p73 and p63 are rarely mutated. We and others have previously reported that human tumor-derived p53 mutants can engage in a physical association with different isoforms of p73, inhibiting their transcriptional activity. Here, we report that human tumor-derived p53 mutants can associate in vitro and in vivo with p63 through their respective core domains. We show that the interaction with mutant p53 impairs in vitro and in vivo sequence-specific DNA binding of p63 and consequently affects its transcriptional activity. We also report that in cells carrying endogenous mutant p53, such as T47D cells, p63 is unable to recruit some of its target gene promoters. Unlike wild-type p53, the binding to specific p53 mutants markedly counteracts p63-induced growth inhibition. This effect is, at least partially, mediated by the core domain of mutant p53. Thus, inactivation of p53 family members may contribute to the biological properties of specific p53 mutants in promoting tumorigenesis and in conferring selective survival advantage to cancer cells.",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/owner" : [ {
      "value" : "NLM",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/lifeskim/mentions" : [ {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0684224",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0086418",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C2911660",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1280500",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C2347695",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0038952",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0332185",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0441655",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1704653",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0596306",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1533691",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0205460",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1306459",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0001721",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1552740",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1509143",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0021469",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1515655",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0033414",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0205227",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1880177",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1704675",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0334227",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1145667",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0522501",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0040649",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1334043",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0206243",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0750490",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1521840",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0086597",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0086860",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0332183",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1326912",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0596988",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1883221",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1882467",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1611821",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0522498",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0597298",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1167622",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1332838",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1513776",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0079419",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1705526",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0812244",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1424677",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1624609",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0080055",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1704257",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1519667",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1422009",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/chemical" : [ {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Histidine",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/DNA",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/CKAP4+protein%2C+human",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/DNA+Primers",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding+Proteins",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Membrane+Proteins",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/TP63+protein%2C+human",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Tumor+Suppressor+Protein+p53",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Tumor+Suppressor+Proteins",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/month" : [ {
      "value" : "May",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/journal" : [ {
      "value" : "http://linkedlifedata.com/resource/pubmed/journal/2985121R",
      "type" : "uri"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#type" : [ {
      "value" : "http://linkedlifedata.com/resource/pubmed/Citation",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/dateCreated" : [ {
      "value" : "2002-5-20",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/issue" : [ {
      "value" : "21",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/day" : [ {
      "value" : "24",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/affiliation" : [ {
      "value" : "Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome 00158, Italy.",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/issnType" : [ {
      "value" : "Print",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/dateRevised" : [ {
      "value" : "2008-6-27",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/publicationType" : [ {
      "value" : "Journal Article",
      "type" : "literal"
    }, {
      "value" : "Research Support, Non-U.S. Gov't",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/authorsComplete" : [ {
      "value" : "Y",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/author" : [ {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/OrenMosheM",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/Del+SalGianninoG",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/CostanzoAntonioA",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/FontemaggiGiuliaG",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/BlandinoGiovanniG",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/LevreroMassimoM",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/SacchiAdaA",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/StranoSabrinaS",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/RizzoMaria+GiuliaMG",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/MontiOlimpiaO",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/BaccariniAlessiaA",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/status" : [ {
      "value" : "MEDLINE",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/year" : [ {
      "value" : "2002",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/volume" : [ {
      "value" : "277",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/citationSubset" : [ {
      "value" : "IM",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/articleTitle" : [ {
      "value" : "Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/meshHeading" : [ {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Base+Sequence",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Binding+Sites",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-DNA",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-DNA+Primers",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-DNA-Binding+Proteins",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Histidine",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Humans",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Phosphoproteins",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Protein+Binding",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Trans-Activators",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Tryptophan",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Tumor+Cells%2C+Cultured",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Tumor+Suppressor+Protein+p53",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Tumor+Suppressor+Proteins",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Genes%2C+Tumor+Suppressor",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Membrane+Proteins",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/11893750-Mutation",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/pagination" : [ {
      "value" : "18817-26",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/issn" : [ {
      "value" : "0021-9258",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/language" : [ {
      "value" : "eng",
      "type" : "literal"
    } ],
    "http://www.w3.org/2004/02/skos/core#exactMatch" : [ {
      "value" : "http://purl.uniprot.org/pubmed/11893750",
      "type" : "uri"
    } ]
  }
}