rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-3-14
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pubmed:abstractText |
Warfarin sodium (warfarin) is commonly prescribed in surgical practice. Warfarin use is complicated by an unpredictable dose response that may be due in part to genetically determined differences in metabolic capacity. To better understand the interaction between genotype and response to warfarin therapy, we determined the frequency and functional effects of polymorphisms of the predominant cytochrome P450 subfamily responsible for warfarin metabolism (eg, CYP2C9) in an ethnically defined U.S. patient population.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1072-7515
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
194
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-73
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11893129-African Americans,
pubmed-meshheading:11893129-Anticoagulants,
pubmed-meshheading:11893129-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:11893129-Cytochrome P-450 Enzyme System,
pubmed-meshheading:11893129-European Continental Ancestry Group,
pubmed-meshheading:11893129-Female,
pubmed-meshheading:11893129-Genotype,
pubmed-meshheading:11893129-Humans,
pubmed-meshheading:11893129-Male,
pubmed-meshheading:11893129-Middle Aged,
pubmed-meshheading:11893129-Polymorphism, Genetic,
pubmed-meshheading:11893129-Prospective Studies,
pubmed-meshheading:11893129-Regression Analysis,
pubmed-meshheading:11893129-Steroid 16-alpha-Hydroxylase,
pubmed-meshheading:11893129-Steroid Hydroxylases,
pubmed-meshheading:11893129-Warfarin
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pubmed:year |
2002
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pubmed:articleTitle |
The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin.
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pubmed:affiliation |
Department of Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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