Source:http://linkedlifedata.com/resource/pubmed/id/11860276
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-3-7
|
| pubmed:abstractText |
Injured dorsal root axons fail to regenerate into the adult spinal cord, leading to permanent sensory loss. We investigated the ability of intrathecal neurotrophin-3 (NT3) to promote axonal regeneration across the dorsal root entry zone (DREZ) and functional recovery in adult rats. Quantitative electron microscopy showed robust penetration of CNS tissue by regenerating sensory axons treated with NT3 at 1 and 2 weeks postrhizotomy. Light and electron microscopical anterograde tracing experiments showed that these axons reentered appropriate and ectopic laminae of the dorsal horn, where they formed vesicle-filled synaptic buttons. Cord dorsum potential recordings confirmed that these were functional. In behavioral studies, NT3-treated (but not untreated or vehicle-treated) rats regained proprioception. Recovery depended on NT3-mediated sensory regeneration: preventing regeneration by root excision prevented recovery. NT3 treatment allows sensory axons to overcome inhibition present at the DREZ and may thus serve to promote functional recovery following dorsal root avulsions in humans.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1044-7431
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| pubmed:author | |
| pubmed:copyrightInfo |
(C)2002 Elsevier Science (USA).
|
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
239-49
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11860276-Animals,
pubmed-meshheading:11860276-Axons,
pubmed-meshheading:11860276-Cholera Toxin,
pubmed-meshheading:11860276-Excitatory Postsynaptic Potentials,
pubmed-meshheading:11860276-Growth Cones,
pubmed-meshheading:11860276-Immunohistochemistry,
pubmed-meshheading:11860276-Microscopy, Electron,
pubmed-meshheading:11860276-Nerve Regeneration,
pubmed-meshheading:11860276-Neuronal Plasticity,
pubmed-meshheading:11860276-Neurotrophin 3,
pubmed-meshheading:11860276-Posterior Horn Cells,
pubmed-meshheading:11860276-Presynaptic Terminals,
pubmed-meshheading:11860276-Proprioception,
pubmed-meshheading:11860276-Radiculopathy,
pubmed-meshheading:11860276-Rats,
pubmed-meshheading:11860276-Recovery of Function,
pubmed-meshheading:11860276-Rhizotomy,
pubmed-meshheading:11860276-Spinal Cord,
pubmed-meshheading:11860276-Spinal Nerve Roots,
pubmed-meshheading:11860276-Synapses,
pubmed-meshheading:11860276-Synaptic Transmission
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Neurotrophin-3-mediated regeneration and recovery of proprioception following dorsal rhizotomy.
|
| pubmed:affiliation |
CORD (Collaboration on Repair Discoveries), The University of British Columbia, Biosciences Building, 6270 University Boulevard, Vancouver, British Columbia V6T 1Z4, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|