| pubmed-article:11839534 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11839534 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:11839534 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:11839534 | lifeskim:mentions | umls-concept:C0036945 | lld:lifeskim |
| pubmed-article:11839534 | lifeskim:mentions | umls-concept:C1533685 | lld:lifeskim |
| pubmed-article:11839534 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:11839534 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:11839534 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:11839534 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11839534 | lifeskim:mentions | umls-concept:C1512912 | lld:lifeskim |
| pubmed-article:11839534 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11839534 | pubmed:dateCreated | 2002-2-12 | lld:pubmed |
| pubmed-article:11839534 | pubmed:abstractText | Antenatal inflammation may be an important triggering event in the pathogenesis of bronchopulmonary dysplasia but may also accelerate fetal lung maturation. We examined the effects of intra-amniotic (IA) interleukin (IL)-1 alpha and IL-1 beta on maturation of the fetal sheep lung. These cytokine effects were compared with IA endotoxin, a potent proinflammatory stimulus that accelerated lung maturation. Date-bred ewes received 15 or 150 microg recombinant ovine IL-1 alpha or IL-1 beta or 10 mg Escherichia coli endotoxin by IA injection at 118 days gestation (term = 150 days), and fetuses were delivered at 125 days. IL-1 alpha and IL-1 beta improved lung function and increased alveolar saturated phosphatidylcholine (Sat PC) and surfactant protein mRNA expression at the higher dose. The maturation response to IL-1 alpha was greater than that to IL-1 beta, which was similar to endotoxin response. Inflammation was also more pronounced after IL-1 alpha treatment. Only endotoxin animals had residual inflammation of the fetal membranes at 7 days. Lung compliance, lung volume, and alveolar Sat PC were positively correlated with residual alveolar wash leukocyte numbers 7 days after IL-1 treatment, suggesting a link between lung inflammation and maturation. | lld:pubmed |
| pubmed-article:11839534 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11839534 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11839534 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11839534 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11839534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11839534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11839534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11839534 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11839534 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11839534 | pubmed:issn | 1040-0605 | lld:pubmed |
| pubmed-article:11839534 | pubmed:author | pubmed-author:SlyPeter DPD | lld:pubmed |
| pubmed-article:11839534 | pubmed:author | pubmed-author:IkegamiMachik... | lld:pubmed |
| pubmed-article:11839534 | pubmed:author | pubmed-author:NewnhamJohn... | lld:pubmed |
| pubmed-article:11839534 | pubmed:author | pubmed-author:WilletKaren... | lld:pubmed |
| pubmed-article:11839534 | pubmed:author | pubmed-author:KramerBoris... | lld:pubmed |
| pubmed-article:11839534 | pubmed:author | pubmed-author:KallapurSuhas... | lld:pubmed |
| pubmed-article:11839534 | pubmed:author | pubmed-author:MossTimothy... | lld:pubmed |
| pubmed-article:11839534 | pubmed:author | pubmed-author:JobeAlan HAH | lld:pubmed |
| pubmed-article:11839534 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11839534 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:11839534 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11839534 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11839534 | pubmed:pagination | L411-20 | lld:pubmed |
| pubmed-article:11839534 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11839534 | pubmed:meshHeading | pubmed-meshheading:11839534... | lld:pubmed |
| pubmed-article:11839534 | pubmed:meshHeading | pubmed-meshheading:11839534... | lld:pubmed |
| pubmed-article:11839534 | pubmed:meshHeading | pubmed-meshheading:11839534... | lld:pubmed |
| pubmed-article:11839534 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11839534 | pubmed:articleTitle | Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung. | lld:pubmed |
| pubmed-article:11839534 | pubmed:affiliation | Division of Clinical Sciences, Center for Child Health Research, Perth, Australia. | lld:pubmed |
| pubmed-article:11839534 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11839534 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11839534 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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