| pubmed-article:11753647 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11753647 | lifeskim:mentions | umls-concept:C0035687 | lld:lifeskim |
| pubmed-article:11753647 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:11753647 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:11753647 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:11753647 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:11753647 | lifeskim:mentions | umls-concept:C1333355 | lld:lifeskim |
| pubmed-article:11753647 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:11753647 | pubmed:issue | 52 | lld:pubmed |
| pubmed-article:11753647 | pubmed:dateCreated | 2001-12-25 | lld:pubmed |
| pubmed-article:11753647 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:abstractText | Human ovarian cancer cells and tissues were examined for the presence or absence of a 42-bp splicing variant of ERCC1 gene, and for a possible functional role of this 42-bp sequence. This specific sequence exists in exon I, the 5'-UTR of the gene. Loss of this 42-bp sequence was associated with increased ERCC1 mRNA expression, in an assessment of 121 ovarian cancer specimens (p2<10(-6)). In cells in tissue culture, the absence of the 42-bp segment was associated with a twofold increased ability to drive transcription in a Luciferase reporter system. Protein can be demonstrated in ovarian cancer cells based on EMSA analysis. Computer analysis shows that this 42-bp sequence contains several binding sites, including a core-binding domain for protein RFX1, transcriptional repressor. These preliminary results lay the groundwork in determination of potential roles for a negative regulatory element in NER repair pathway. | lld:pubmed |
| pubmed-article:11753647 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11753647 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11753647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11753647 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11753647 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11753647 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:11753647 | pubmed:author | pubmed-author:GuoYY | lld:pubmed |
| pubmed-article:11753647 | pubmed:author | pubmed-author:ReedEE | lld:pubmed |
| pubmed-article:11753647 | pubmed:author | pubmed-author:YuJ JJJ | lld:pubmed |
| pubmed-article:11753647 | pubmed:author | pubmed-author:ThorntonKK | lld:pubmed |
| pubmed-article:11753647 | pubmed:author | pubmed-author:KotzHH | lld:pubmed |
| pubmed-article:11753647 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11753647 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11753647 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11753647 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11753647 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11753647 | pubmed:pagination | 7694-8 | lld:pubmed |
| pubmed-article:11753647 | pubmed:dateRevised | 2008-9-5 | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
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| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
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| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:meshHeading | pubmed-meshheading:11753647... | lld:pubmed |
| pubmed-article:11753647 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11753647 | pubmed:articleTitle | An ERCC1 splicing variant involving the 5'-UTR of the mRNA may have a transcriptional modulatory function. | lld:pubmed |
| pubmed-article:11753647 | pubmed:affiliation | West Virginia University, Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, 1801 Health Sciences South, P.O. Box 9300, Morgantown, WV 26506-9300, USA. | lld:pubmed |
| pubmed-article:11753647 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11753647 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:2067 | entrezgene:pubmed | pubmed-article:11753647 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11753647 | lld:pubmed |
