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rdf:type |
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lifeskim:mentions |
umls-concept:C0001721,
umls-concept:C0007600,
umls-concept:C0011065,
umls-concept:C0012854,
umls-concept:C0028040,
umls-concept:C0037083,
umls-concept:C0278996,
umls-concept:C0334227,
umls-concept:C0392756,
umls-concept:C0450442,
umls-concept:C0871261,
umls-concept:C1704259,
umls-concept:C1704632,
umls-concept:C1705987,
umls-concept:C1706817,
umls-concept:C1710082,
umls-concept:C2911692
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pubmed:issue |
10
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pubmed:dateCreated |
2001-10-9
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pubmed:abstractText |
Growing evidence suggests that tobacco can affect the responsiveness of cancer cells to treatment, particularly those of head and neck cancer. This article describes the effects of nicotine on the signaling of the death pathway, resulting in a decreased cytotoxicity of various anticancer agents such as cisplatin and gamma-radiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DDIT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Adducts,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotine,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor CHOP,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1043-3074
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 John Wiley & Sons, Inc. Head Neck 23: 860-870, 2001.
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
860-70
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11592233-Antineoplastic Agents,
pubmed-meshheading:11592233-Apoptosis,
pubmed-meshheading:11592233-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:11592233-Colony-Forming Units Assay,
pubmed-meshheading:11592233-DNA Adducts,
pubmed-meshheading:11592233-DNA Damage,
pubmed-meshheading:11592233-DNA Fragmentation,
pubmed-meshheading:11592233-Head and Neck Neoplasms,
pubmed-meshheading:11592233-Humans,
pubmed-meshheading:11592233-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:11592233-MAP Kinase Kinase 4,
pubmed-meshheading:11592233-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:11592233-Nicotine,
pubmed-meshheading:11592233-Nicotinic Agonists,
pubmed-meshheading:11592233-Signal Transduction,
pubmed-meshheading:11592233-Transcription Factor CHOP,
pubmed-meshheading:11592233-Transcription Factors,
pubmed-meshheading:11592233-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents.
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pubmed:affiliation |
UCSD Cancer Center 0058, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0058, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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