pubmed-article:11526232 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11526232 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
pubmed-article:11526232 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:11526232 | lifeskim:mentions | umls-concept:C0162340 | lld:lifeskim |
pubmed-article:11526232 | lifeskim:mentions | umls-concept:C0035547 | lld:lifeskim |
pubmed-article:11526232 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
pubmed-article:11526232 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
pubmed-article:11526232 | pubmed:issue | 18 | lld:pubmed |
pubmed-article:11526232 | pubmed:dateCreated | 2001-8-29 | lld:pubmed |
pubmed-article:11526232 | pubmed:abstractText | Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides. Class I RNRs are composed of two homodimeric subunits: R1 and R2. R1 is directly involved in the reduction, and R2 contains the diferric-tyrosyl radical (Y*) cofactor essential for the initiation of reduction. Saccharomyces cerevisiae has two RNRs; Y1 and Y3 correspond to R1, whereas Y2 and Y4 correspond to R2. Y4 is essential for diferric-Y* formation in Y2 from apoY2, Fe(2+), and O(2). The actual function of Y4 is controversial. Y2 and Y4 have been further characterized in an effort to understand their respective roles in nucleotide reduction. (His)(6)-Y2, Y4, and (His)(6)-Y4 are homodimers, isolated largely in apo form. Their CD spectra reveal that they are predominantly helical. The concentrations of Y2 and Y4 in vivo are 0.5-2.3 microM, as determined by Western analysis. Incubation of Y2 and Y4 under physiological conditions generates apo Y2Y4 heterodimer, which can form a diferric-Y small middle dot when incubated with Fe(2+) and O(2). Holo Y2Y4 heterodimer contains 0.6-0.8 Y* and has a specific activity of 0.8-1.3 micromol.min.mg. Titration of Y2 with Y4 in the presence of Fe(2+) and O(2) gives maximal activity with one equivalent of Y4 per Y2. Models for the function of Y4 based on these data and the accompanying structure will be discussed. | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:language | eng | lld:pubmed |
pubmed-article:11526232 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11526232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11526232 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11526232 | pubmed:month | Aug | lld:pubmed |
pubmed-article:11526232 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:11526232 | pubmed:author | pubmed-author:KEF HFH | lld:pubmed |
pubmed-article:11526232 | pubmed:author | pubmed-author:BøBB | lld:pubmed |
pubmed-article:11526232 | pubmed:author | pubmed-author:GriffinR GRG | lld:pubmed |
pubmed-article:11526232 | pubmed:author | pubmed-author:StubbsDD | lld:pubmed |
pubmed-article:11526232 | pubmed:author | pubmed-author:NguyenH HHH | lld:pubmed |
pubmed-article:11526232 | pubmed:author | pubmed-author:PerlsteinD... | lld:pubmed |
pubmed-article:11526232 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11526232 | pubmed:day | 28 | lld:pubmed |
pubmed-article:11526232 | pubmed:volume | 98 | lld:pubmed |
pubmed-article:11526232 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11526232 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11526232 | pubmed:pagination | 10067-72 | lld:pubmed |
pubmed-article:11526232 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:meshHeading | pubmed-meshheading:11526232... | lld:pubmed |
pubmed-article:11526232 | pubmed:year | 2001 | lld:pubmed |
pubmed-article:11526232 | pubmed:articleTitle | Why multiple small subunits (Y2 and Y4) for yeast ribonucleotide reductase? Toward understanding the role of Y4. | lld:pubmed |
pubmed-article:11526232 | pubmed:affiliation | Department of Chemistry, Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. | lld:pubmed |
pubmed-article:11526232 | pubmed:publicationType | Journal Article | lld:pubmed |
entrez-gene:853427 | entrezgene:pubmed | pubmed-article:11526232 | lld:entrezgene |
entrez-gene:853091 | entrezgene:pubmed | pubmed-article:11526232 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11526232 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11526232 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11526232 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11526232 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11526232 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11526232 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11526232 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11526232 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11526232 | lld:pubmed |