| pubmed-article:11406608 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11406608 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11406608 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:11406608 | lifeskim:mentions | umls-concept:C0024305 | lld:lifeskim |
| pubmed-article:11406608 | lifeskim:mentions | umls-concept:C0005576 | lld:lifeskim |
| pubmed-article:11406608 | lifeskim:mentions | umls-concept:C0032529 | lld:lifeskim |
| pubmed-article:11406608 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:11406608 | pubmed:dateCreated | 2001-6-14 | lld:pubmed |
| pubmed-article:11406608 | pubmed:abstractText | Considering the role in the metabolism of chemicals played by biotransformation enzymes, we aimed at determining whether any association exists between genetic polymorphisms in CYP1A1, CYP2E1, epoxide hydrolase (EPHX), glutathione S-transferases (GSTM1/P1/T1) and individual susceptibility to lymphomas. PCR-RFLP-based genotyping assays were used to determine the frequency of polymorphisms in CYP1A1 (3'-flanking region), CYP2E1 (5'-flanking region and intron 6), EPHX (exons 3 and 4), GSTM1 (deletion), GSTP1 (exon 5) and GSTT1 (deletion) in a case-control study comprised of 219 patients with morbus Hodgkin (MH) and non-Hodgkin's lymphomas (NHL) and 455 age- and sex-matched healthy individuals. The distribution of genotypes in CYP2E1-intron 6 was significantly different between the control group and all lymphomas (P = 0.03), patients with NHL (P = 0.024), and especially aggressive diffuse NHL (P = 0.007). Grading of NHL seemed to be associated with this polymorphism as well (P = 0.041). The EPHX-exon 3 genotype distribution was significantly different between control males and males with all lymphomas (P = 0.01) or with NHL (P = 0.019). The Val/Val genotype of GSTP1-exon 5 was prevalent in all MH [odds ratio (OR) = 2.08, 95% confidence interval (CI) = 1.05-4.14] and this difference was particularly evident in females (OR = 2.97, 95% CI = 1.16-7.61). A significant difference in the distribution of GSTP1-exon 5 genotypes was found between NHL tumors >5 cm and those <5 cm (P = 0.03). The results suggest that genetic polymorphisms of biotransformation enzymes may play a significant role in the development of lymphoid malignancies. | lld:pubmed |
| pubmed-article:11406608 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11406608 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11406608 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11406608 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11406608 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11406608 | pubmed:issn | 0964-6906 | lld:pubmed |
| pubmed-article:11406608 | pubmed:author | pubmed-author:GutII | lld:pubmed |
| pubmed-article:11406608 | pubmed:author | pubmed-author:SoucekPP | lld:pubmed |
| pubmed-article:11406608 | pubmed:author | pubmed-author:BenesováKK | lld:pubmed |
| pubmed-article:11406608 | pubmed:author | pubmed-author:SarmanováJJ | lld:pubmed |
| pubmed-article:11406608 | pubmed:author | pubmed-author:TynkováLL | lld:pubmed |
| pubmed-article:11406608 | pubmed:author | pubmed-author:Nedelcheva-Kr... | lld:pubmed |
| pubmed-article:11406608 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11406608 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11406608 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:11406608 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11406608 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11406608 | pubmed:pagination | 1265-73 | lld:pubmed |
| pubmed-article:11406608 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11406608 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11406608 | pubmed:articleTitle | Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas. | lld:pubmed |
| pubmed-article:11406608 | pubmed:affiliation | Biotransformations Group, Center of Occupational Diseases, National Institute of Public Health, Srobárova 48, Praha 10, 100 42, Czech Republic,. | lld:pubmed |
| pubmed-article:11406608 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11406608 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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