Source:http://linkedlifedata.com/resource/pubmed/id/11406608
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2001-6-14
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| pubmed:abstractText |
Considering the role in the metabolism of chemicals played by biotransformation enzymes, we aimed at determining whether any association exists between genetic polymorphisms in CYP1A1, CYP2E1, epoxide hydrolase (EPHX), glutathione S-transferases (GSTM1/P1/T1) and individual susceptibility to lymphomas. PCR-RFLP-based genotyping assays were used to determine the frequency of polymorphisms in CYP1A1 (3'-flanking region), CYP2E1 (5'-flanking region and intron 6), EPHX (exons 3 and 4), GSTM1 (deletion), GSTP1 (exon 5) and GSTT1 (deletion) in a case-control study comprised of 219 patients with morbus Hodgkin (MH) and non-Hodgkin's lymphomas (NHL) and 455 age- and sex-matched healthy individuals. The distribution of genotypes in CYP2E1-intron 6 was significantly different between the control group and all lymphomas (P = 0.03), patients with NHL (P = 0.024), and especially aggressive diffuse NHL (P = 0.007). Grading of NHL seemed to be associated with this polymorphism as well (P = 0.041). The EPHX-exon 3 genotype distribution was significantly different between control males and males with all lymphomas (P = 0.01) or with NHL (P = 0.019). The Val/Val genotype of GSTP1-exon 5 was prevalent in all MH [odds ratio (OR) = 2.08, 95% confidence interval (CI) = 1.05-4.14] and this difference was particularly evident in females (OR = 2.97, 95% CI = 1.16-7.61). A significant difference in the distribution of GSTP1-exon 5 genotypes was found between NHL tumors >5 cm and those <5 cm (P = 0.03). The results suggest that genetic polymorphisms of biotransformation enzymes may play a significant role in the development of lymphoid malignancies.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2E1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Epoxide Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0964-6906
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
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| pubmed:volume |
10
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1265-73
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:11406608-Alleles,
pubmed-meshheading:11406608-Biotransformation,
pubmed-meshheading:11406608-Case-Control Studies,
pubmed-meshheading:11406608-Cytochrome P-450 CYP1A1,
pubmed-meshheading:11406608-Cytochrome P-450 CYP2E1,
pubmed-meshheading:11406608-Cytochrome P-450 Enzyme System,
pubmed-meshheading:11406608-Epoxide Hydrolases,
pubmed-meshheading:11406608-Exons,
pubmed-meshheading:11406608-Female,
pubmed-meshheading:11406608-Genetic Predisposition to Disease,
pubmed-meshheading:11406608-Genotype,
pubmed-meshheading:11406608-Glutathione Transferase,
pubmed-meshheading:11406608-Hodgkin Disease,
pubmed-meshheading:11406608-Humans,
pubmed-meshheading:11406608-Lymphoma, Non-Hodgkin,
pubmed-meshheading:11406608-Male,
pubmed-meshheading:11406608-Middle Aged,
pubmed-meshheading:11406608-Polymorphism, Genetic
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| pubmed:year |
2001
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| pubmed:articleTitle |
Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas.
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| pubmed:affiliation |
Biotransformations Group, Center of Occupational Diseases, National Institute of Public Health, Srobárova 48, Praha 10, 100 42, Czech Republic,.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|