Source:http://linkedlifedata.com/resource/pubmed/id/11313950
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2001-4-23
|
| pubmed:databankReference | |
| pubmed:abstractText |
The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the ability of avian myeloblastosis virus (AMV) to transform myelomonocytic cells. v-Myb is thought to disrupt the differentiation of myelomonocytic cells by affecting the expression of specific target genes. To identify such genes we have analysed the gene expression in a myelomonocytic chicken cell line that carries an estrogen inducible version of v-Myb by differential display. Here we describe the identification of the chicken homolog of the mouse Pdcd4 gene as a novel v-Myb target gene. Pdcd4 is also known as MA-3, TIS and H731 and has recently been shown to suppress the transformation of epidermal cells by tumor promoters. Our results provide the first evidence that v-Myb directly regulates the expression of a potential tumor suppressor gene.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0950-9232
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
11
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
231-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11313950-Alpharetrovirus,
pubmed-meshheading:11313950-Amino Acid Sequence,
pubmed-meshheading:11313950-Animals,
pubmed-meshheading:11313950-Apoptosis,
pubmed-meshheading:11313950-Avian myeloblastosis virus,
pubmed-meshheading:11313950-Base Sequence,
pubmed-meshheading:11313950-Cell Nucleus,
pubmed-meshheading:11313950-Cells, Cultured,
pubmed-meshheading:11313950-Chickens,
pubmed-meshheading:11313950-Cytarabine,
pubmed-meshheading:11313950-Gene Expression Regulation,
pubmed-meshheading:11313950-Molecular Sequence Data,
pubmed-meshheading:11313950-Myeloid Cells,
pubmed-meshheading:11313950-Oncogene Proteins v-myb,
pubmed-meshheading:11313950-Proteins,
pubmed-meshheading:11313950-RNA-Binding Proteins,
pubmed-meshheading:11313950-Sequence Homology, Amino Acid,
pubmed-meshheading:11313950-Thymus Gland,
pubmed-meshheading:11313950-Ultraviolet Rays
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
The chicken Pdcd4 gene is regulated by v-Myb.
|
| pubmed:affiliation |
Institut für Biochemie, Westfälische-Wilhelms-Universität Münster, Wilhelm-Klemm-Str. 2, D-48149 Münster, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|