Linked Life Data

1127254

Source:http://linkedlifedata.com/resource/pubmed/id/1127254

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1975-8-4
pubmed:abstractText
A penicillin-sensitive strain of Staphylococcus aureus was used to evaluate the efficacy of six antibiotic combinations in the therapy of an experimental infection in mice. One hour after intraperitoneal infection, animals were treated with penicillin G, erythromycin, clindamycin, gentamcicin, or tobramycin singly or in various combinations of two of these drugs. Penicillin in combination with tobramycin, gentamicin, or ertyromycin significantly reduced mortality was compared with therapy with a single drug. Survival of animals treated with the combinations of penicillin and clindamycin, clindamycin and gentamicin, and erythromycin and gentamicin was not different from that seen with single-drug therapy. Pencillin plus either gentamicin or erythromycin significantly reduced the number of culturable organisms from livers and spleens of infected animals when compared with penicillin, gentamicin, or erythromycin alone. In vitro studies correlaed with some aspects of in vivo results but conflicted with others. Thus the combination of penicillin with either an aminoglycoside antibotic or erythromycin is more effective than a single drug in the therapy of infection caused by the Smith strain of S. aureus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-51
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Antibiotic combinations in the treatment of experimental Staphylococcus aureus infection.
pubmed:publicationType
Journal Article