Source:http://linkedlifedata.com/resource/pubmed/id/11212229
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2001-2-9
|
| pubmed:abstractText |
Microarray analysis is a promising new approach for creating specific expression profiles of multiple genes simultaneously. We quantitatively analyzed differential gene expression patterns in mycosis fungoides-derived clonal T cells and autologous, identically cultured CD4+ lymphocytes using microarrays containing 588 cDNA segments from genes relevant to cell signaling, carcinogenesis, and apoptosis. Among other dissimilarities, neoplastic T cells showed coexpression of CD40 (Bp50) and CD40 ligand (gp39, CD154). These results could be corroborated by reverse transcription-PCR, immunohistochemistry, and two-color immunofluorescence staining. Our data suggest that in cutaneous T-cell lymphoma, CD40/CD40 ligand interactions might represent a paracrine loop that is crucial not only in preventing apoptosis or positively regulating growth but also in homing of neoplastic cells to the skin.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
61
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
452-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11212229-Adult,
pubmed-meshheading:11212229-Aged,
pubmed-meshheading:11212229-Aged, 80 and over,
pubmed-meshheading:11212229-Antigens, CD40,
pubmed-meshheading:11212229-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11212229-CD40 Ligand,
pubmed-meshheading:11212229-DNA, Complementary,
pubmed-meshheading:11212229-Female,
pubmed-meshheading:11212229-Gene Expression Profiling,
pubmed-meshheading:11212229-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11212229-Humans,
pubmed-meshheading:11212229-Immunohistochemistry,
pubmed-meshheading:11212229-Lymphoma, T-Cell, Cutaneous,
pubmed-meshheading:11212229-Male,
pubmed-meshheading:11212229-Middle Aged,
pubmed-meshheading:11212229-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:11212229-RNA, Messenger,
pubmed-meshheading:11212229-Skin Neoplasms,
pubmed-meshheading:11212229-T-Lymphocytes,
pubmed-meshheading:11212229-Tumor Cells, Cultured
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Coexpression of CD40 and CD40 ligand in cutaneous T-cell lymphoma (mycosis fungoides).
|
| pubmed:affiliation |
Department of Dermatology, University Hospital of Zurich, Switzerland.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|