| pubmed-article:11086024 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11086024 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:11086024 | lifeskim:mentions | umls-concept:C0029453 | lld:lifeskim |
| pubmed-article:11086024 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:11086024 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:11086024 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:11086024 | lifeskim:mentions | umls-concept:C1999177 | lld:lifeskim |
| pubmed-article:11086024 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11086024 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11086024 | pubmed:dateCreated | 2000-12-4 | lld:pubmed |
| pubmed-article:11086024 | pubmed:abstractText | Estrogen deficiency induces bone loss by upregulating osteoclastogenesis by mechanisms not completely defined. We found that ovariectomy-enhanced T-cell production of TNF-alpha, which, acting through the TNF-alpha receptor p55, augments macrophage colony-stimulating factor-induced (M-CSF-induced) and RANKL-induced osteoclastogenesis. Ovariectomy failed to induce bone loss, stimulate bone resorption, or increase M-CSF- and RANKL-dependent osteoclastogenesis in T-cell deficient mice, establishing T cells as essential mediators of the bone-wasting effects of estrogen deficiency in vivo. These findings demonstrate that the ability of estrogen to target T cells, suppressing their production of TNF-alpha, is a key mechanism by which estrogen prevents osteoclastic bone resorption and bone loss. | lld:pubmed |
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| pubmed-article:11086024 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11086024 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11086024 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11086024 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11086024 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11086024 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:11086024 | pubmed:author | pubmed-author:NambaNN | lld:pubmed |
| pubmed-article:11086024 | pubmed:author | pubmed-author:WoodringJJ | lld:pubmed |
| pubmed-article:11086024 | pubmed:author | pubmed-author:WeitzmannM... | lld:pubmed |
| pubmed-article:11086024 | pubmed:author | pubmed-author:PacificiRR | lld:pubmed |
| pubmed-article:11086024 | pubmed:author | pubmed-author:NovackDD | lld:pubmed |
| pubmed-article:11086024 | pubmed:author | pubmed-author:RoggiaCC | lld:pubmed |
| pubmed-article:11086024 | pubmed:author | pubmed-author:CenciSS | lld:pubmed |
| pubmed-article:11086024 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11086024 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:11086024 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11086024 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11086024 | pubmed:pagination | 1229-37 | lld:pubmed |
| pubmed-article:11086024 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11086024 | pubmed:meshHeading | pubmed-meshheading:11086024... | lld:pubmed |
