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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-7-24
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pubmed:abstractText |
The influence of whole-cell and acellular pertussis vaccines, introduced both alone and in combination with N-acetylglucosaminylmuramyl-2-alanine-D-isoglutamine (GMDP) on the activity of two enzymes of peritoneal exudate macrophages (5'-nucleotidase and Na+K(+)-adenosine triphosphatase) was studied. The study revealed that both pertussis vaccines exhibited immunomodulating properties, these properties being most pronounced in whole-cell pertussis vaccine. The use of GMDP in combination with pertussis vaccines led to changes in the enzymatic activity of peritoneal exudate macrophages, which was indicative of a decrease in the immunomodulating action of pertussis preparations.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0372-9311
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
56-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10876852-5'-Nucleotidase,
pubmed-meshheading:10876852-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:10876852-Adenosine Triphosphatases,
pubmed-meshheading:10876852-Adjuvants, Immunologic,
pubmed-meshheading:10876852-Animals,
pubmed-meshheading:10876852-Ascitic Fluid,
pubmed-meshheading:10876852-Dose-Response Relationship, Drug,
pubmed-meshheading:10876852-Macrophages, Peritoneal,
pubmed-meshheading:10876852-Mice,
pubmed-meshheading:10876852-Mice, Inbred C57BL,
pubmed-meshheading:10876852-Mice, Inbred CBA,
pubmed-meshheading:10876852-Pertussis Vaccine,
pubmed-meshheading:10876852-Vaccines, Inactivated
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pubmed:articleTitle |
[The action of pertussis vaccines and GMDP on the change in the enzymatic activity of macrophages from peritoneal exudate].
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pubmed:affiliation |
Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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