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rdf:type |
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lifeskim:mentions |
umls-concept:C0009017,
umls-concept:C0015576,
umls-concept:C0024660,
umls-concept:C0025914,
umls-concept:C0026179,
umls-concept:C0026809,
umls-concept:C0031727,
umls-concept:C0205314,
umls-concept:C0228174,
umls-concept:C0443281,
umls-concept:C0679622,
umls-concept:C0680022,
umls-concept:C1415014,
umls-concept:C1416563,
umls-concept:C1417019,
umls-concept:C1527148,
umls-concept:C1537698
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pubmed:issue |
1
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pubmed:dateCreated |
2000-4-10
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pubmed:databankReference |
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pubmed:abstractText |
A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues and various developmental stages of the mouse brain. MINK encodes a 1300 amino acid polypeptide, consisting of an N-terminal kinase domain, a proline-rich intermediate region, and a C-terminal GCK homology region. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author |
pubmed-author:DayDD,
pubmed-author:FukagayaYY,
pubmed-author:KajikawaEE,
pubmed-author:KimuraW KWK,
pubmed-author:KobayashiTT,
pubmed-author:KusumiAA,
pubmed-author:MatsumotoKK,
pubmed-author:NakashimaT MTM,
pubmed-author:Ninomiya-TsujiJJ,
pubmed-author:WatanabeN MNM,
pubmed-author:Yamashita-SuzukiKK
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
469
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-23
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10708748-Amino Acid Sequence,
pubmed-meshheading:10708748-Animals,
pubmed-meshheading:10708748-Brain,
pubmed-meshheading:10708748-Cell Line,
pubmed-meshheading:10708748-Cloning, Molecular,
pubmed-meshheading:10708748-Enzyme Activation,
pubmed-meshheading:10708748-Gene Expression Regulation, Developmental,
pubmed-meshheading:10708748-Mice,
pubmed-meshheading:10708748-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10708748-Molecular Sequence Data,
pubmed-meshheading:10708748-Nerve Tissue Proteins,
pubmed-meshheading:10708748-Phylogeny,
pubmed-meshheading:10708748-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10708748-RNA, Messenger,
pubmed-meshheading:10708748-Signal Transduction,
pubmed-meshheading:10708748-Transfection,
pubmed-meshheading:10708748-Up-Regulation
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pubmed:year |
2000
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pubmed:articleTitle |
Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development.
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pubmed:affiliation |
Kusumi Membrane Organizer Project, ERATO, JST, 5-11-33 Chiyoda, Nagoya, Japan.
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pubmed:publicationType |
Journal Article
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