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pubmed-article:10704237pubmed:abstractTextThe expression of fas gene in glioma cells varies with growth stage. When insulin-elicited transient apoptosis of glioma cells was in progress, the expression of fas gene increased at both transcriptional and translational levels. In contrast, the expression of fas-L gene in glioma cells remained constant. Apoptosis occurred in the cells having high level of surface Fas protein. When the expression of Fas-L in U-373MG cells was suppressed by ribozyme, the insulin-elicited transient apoptosis vanished. Overexpression of Bcl-2 in U-373MG cells did not alter significantly the cell cycle progression and the expression of fas gene. However, these cells were resistant to insulin-trigged death. Therefore, insulin-elicited apoptosis involved Fas-related death signal, and which could be prevented by the protective effect of Bcl-2.lld:pubmed
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pubmed-article:10704237pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:10704237pubmed:articleTitleTransient apoptosis elicited by insulin in serum-starved glioma cells involves Fas/Fas-L and Bcl-2.lld:pubmed
pubmed-article:10704237pubmed:affiliationDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. y1357@mail.ncku.edu.twlld:pubmed
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