Linked Life Data

10592381

Source:http://linkedlifedata.com/resource/pubmed/id/10592381

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-1-13
pubmed:abstractText
An in vitro lateral thoracic skin preparation of the adult rat was used to test the effect of serotonin (5, 50, 500 microM) and control solutions on the response of the type I slowly adapting mechanoreceptor to a standard mechanical stimulus. Serotonin (5-HT) significantly increased the magnitude of the type I response to mechanical indentation: 50 microM 5-HT infusion enhanced responsiveness more effectively than 5 microM 5-HT. In the absence of mechanical stimulation, little or no change in spontaneous discharge relative to control was observed, and recovery to baseline levels occurred within three stimulus trials. In vitro and in vivo control experiments showed no statistically significant change in responsiveness over a similar number of stimulus cycles. It was concluded that 5-HT modulates, but does not activate the rat type I receptor or alter its ability to encode the depth and/or velocity of mechanical displacement.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1422-4933
pubmed:author
pubmed:copyrightInfo
Copyright 1999 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
382-9
pubmed:dateRevised
2009-12-16
pubmed:meshHeading
pubmed:articleTitle
Chemosensitivity of the rat type I slowly adapting mechanoreceptor.
pubmed:affiliation
Department of Physiology, University of Utah School of Medicine, Salt Lake City, UT 84108-1270, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.