Source:http://linkedlifedata.com/resource/pubmed/id/10583166
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2000-5-2
|
| pubmed:abstractText |
Adherence to host surfaces is an essential prerequisite for colonization and infection. We compared the adherence of 15 oral isolates of Candida albicans harvested from human immunodeficiency virus (HIV)-infected individuals and 12 isolates from HIV-free individuals to buccal epithelial cells (BECs) from HIV-free individuals, and the adherence of a reference strain of C. albicans to BECs from HIV-infected as well as HIV-free individuals. C. albicans from HIV-infected individuals showed adherence values similar to those from HIV-free individuals. The clinical and laboratory parameters of the subjects from whom the Candida were isolated did not correlate with adherence. A reference strain of C. albicans (GDH 1957), however, adhered more readily to BECs from HIV-infected individuals than to cells from an HIV-free cohort. Several variables were found to be associated with the adherence of C. albicans to BECs from HIV-infected individuals: use of zidovudine, antibacterials and antiparasitics was associated with increased adhesion, while haemophilia, heterosexuality, bisexuality, increased age, decreased CD4 + count and use of folate were associated with a decreased candidal adhesion (all P < 0.05). Our data suggest that the quality of BECs including their receptivity to Candida may play an important part in increasing the oral yeast carriage in HIV infection.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0007-0963
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
141
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
852-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10583166-AIDS-Related Opportunistic Infections,
pubmed-meshheading:10583166-Adult,
pubmed-meshheading:10583166-Candida albicans,
pubmed-meshheading:10583166-Candidiasis, Oral,
pubmed-meshheading:10583166-Cell Adhesion,
pubmed-meshheading:10583166-Cell Culture Techniques,
pubmed-meshheading:10583166-Epithelial Cells,
pubmed-meshheading:10583166-Female,
pubmed-meshheading:10583166-Humans,
pubmed-meshheading:10583166-Logistic Models,
pubmed-meshheading:10583166-Male,
pubmed-meshheading:10583166-Mouth Mucosa
|
| pubmed:year |
1999
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| pubmed:articleTitle |
Factors affecting the adherence of Candida albicans to human buccal epithelial cells in human immunodeficiency virus infection.
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| pubmed:affiliation |
Faculty of Dentistry, University of Hong Kong, The Prince Philip Dental Hospital, Hong Kong.
|
| pubmed:publicationType |
Journal Article
|