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pubmed-article:10527644pubmed:abstractTextThe effects of buprenorphine (0.0125-0.2 mg kg(-1)) on the locomotor activity of rats were determined 1-2 months after ceasing a chronic treatment with morphine (20 mg kg(-1)for 28 days). In control animals buprenorphine exhibited both depressive and stimulatory actions, as repeatedly described for morphine. In post-dependent animals buprenorphine showed a depressive effect similar to that observed in naive ones. On the contrary, a persistent sensitization to the excitatory effect was observed; the degree of cross-sensitization was similar to that of morphine itself (20 mg kg(-1)). The results are discussed in terms of persistent changes in the locomotor response to opioids, possibly correlated to both drug craving and relapse.lld:pubmed
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pubmed-article:10527644pubmed:copyrightInfoCopyright 1999 Academic Press.lld:pubmed
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pubmed-article:10527644pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:10527644pubmed:articleTitleEffects of buprenorphine on motility in morphine post-dependent rats.lld:pubmed
pubmed-article:10527644pubmed:affiliationDepartment of Pharmacology, University of Bologna, Via Irnerio 48, Bologna, I-40126, Italy.lld:pubmed
pubmed-article:10527644pubmed:publicationTypeJournal Articlelld:pubmed