Source:http://linkedlifedata.com/resource/pubmed/id/10509927
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
18
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| pubmed:dateCreated |
1999-11-4
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| pubmed:abstractText |
Resistance to carbapenem antibiotics in gram-negative bacteria is due, in part, to expression of a wide spectrum metallo-beta-lactamase, which renders the drug inactive. Biphenyl tetrazoles containing 3-n-butyl-1-phenylpyrazole-5-carboxylates or the corresponding 5-ethyl esters were found to inhibit metallo-beta-lactamases as well as renal dehydropeptidase I to a lesser extent.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2741-6
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| pubmed:dateRevised |
2000-12-18
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| pubmed:meshHeading | |
| pubmed:year |
1999
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| pubmed:articleTitle |
Structure-activity relationships of biphenyl tetrazoles as metallo-beta-lactamase inhibitors.
|
| pubmed:affiliation |
Department of Biochemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA.
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| pubmed:publicationType |
Journal Article
|