Linked Life Data

10359479

Source:http://linkedlifedata.com/resource/pubmed/id/10359479

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-8-30
pubmed:abstractText
Winter depressions in seasonal affective disorder (SAD) are associated with central serotonergic (5-HT) dysfunction. SAD patients demonstrate rather specific, state-dependent, abnormal increases in 'activation-euphoria' ratings following intravenous infusion of the 5-HT receptor agonist meta-chlorophenylpiperazine (m-CPP). Several studies are also consistent with abnormal serotonergic regulation of the hypothalamic-pituitary-adrenal (HPA) axis in SAD. Here, we investigated the effects of the 5-HT1A receptor partial agonist ipsapirone, which produces behavioral effects and HPA-axis activation, to further characterize the 5-HT receptor subtype-specificity of these disturbances in SAD. Eighteen SAD patients and 18 control subjects completed two drug challenges (ipsapirone 0.3 mg/kg and placebo) separated by 3-5 days in randomized order. We measured behavioral responses with the NIMH self-rating scale, and plasma ACTH, cortisol, and prolactin concentrations. Compared with placebo, ipsapirone was associated with significant increases in self-rated 'functional deficit' and 'altered self-reality', and in each of the hormones. There were no differences between groups on any measures. The level of depression in SAD patients was inversely correlated with their ipsapirone-induced cortisol responses. There were significant drug x order effects on baseline 'anxiety' scores, ACTH and cortisol concentrations, such that subjects were significantly more stressed (higher 'anxiety', ACTH and cortisol) prior to their first challenge compared with their second. In conclusion, post-synaptic 5-HT1A receptors appear to function normally in SAD. The previously observed m-CPP-induced behavioral abnormality may be mediated by either 5-HT2C or 5-HT7 receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0165-1781
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-28
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:10359479-Adrenocorticotropic Hormone, pubmed-meshheading:10359479-Adult, pubmed-meshheading:10359479-Depression, pubmed-meshheading:10359479-Female, pubmed-meshheading:10359479-Humans, pubmed-meshheading:10359479-Hydrocortisone, pubmed-meshheading:10359479-Hypothalamo-Hypophyseal System, pubmed-meshheading:10359479-Infusions, Intravenous, pubmed-meshheading:10359479-Male, pubmed-meshheading:10359479-Piperazines, pubmed-meshheading:10359479-Pituitary-Adrenal System, pubmed-meshheading:10359479-Prolactin, pubmed-meshheading:10359479-Pyrimidines, pubmed-meshheading:10359479-Receptors, Serotonin, pubmed-meshheading:10359479-Retrospective Studies, pubmed-meshheading:10359479-Seasonal Affective Disorder, pubmed-meshheading:10359479-Serotonin, pubmed-meshheading:10359479-Serotonin Receptor Agonists
pubmed:year
1999
pubmed:articleTitle
Serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-HT(1A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects.
pubmed:affiliation
University of Cincinnati College of Medicine, Department of Psychiatry and VAMC, OH, USA. pjs4@popd.ix.netcom.com
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial