Linked Life Data

10331975

Source:http://linkedlifedata.com/resource/pubmed/id/10331975

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1999-7-22
pubmed:abstractText
Mammalian Tolloid-like 1 (mTLL-1) is an astacin-like metalloprotease, highly similar in domain structure to the morphogenetically important proteases bone morphogenetic protein-1 (BMP-1) and Drosophila Tolloid. To investigate possible roles for mTLL-1 in mammalian development, we have used gene targeting in ES cells to produce mice with a disrupted allele for the corresponding gene, Tll1. Homozygous mutants were embryonic lethal, with death at mid-gestation from cardiac failure and a unique constellation of developmental defects that were apparently confined solely to the heart. Constant features were incomplete formation of the muscular interventricular septum and an abnormal and novel positioning of the heart and aorta. Consistent with roles in cardiac development, Tll1 expression was specific to precardiac tissue and endocardium in 7.5 and 8.5 days p.c. embryos, respectively. Tll1 expression was also high in the developing interventricular septum, where expression of the BMP-1 gene, Bmp1, was not observed. Cardiac structures that were not affected in Tll1-/- embryos either showed no Tll1 expression (atrio-ventricular cushions) or showed overlapping expression of Tll1 and Bmp1 (aortico-pulmonary septum), suggesting that products of the Bmp1 gene may be capable of functionally substituting for mTLL-1 at sites in which they are co-expressed. Together, the various data show that mTLL-1 plays multiple roles in formation of the mammalian heart and is essential for formation of the interventricular septum.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2631-42
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10331975-Animals, pubmed-meshheading:10331975-Bone Morphogenetic Protein 1, pubmed-meshheading:10331975-Bone Morphogenetic Proteins, pubmed-meshheading:10331975-Female, pubmed-meshheading:10331975-Fetal Death, pubmed-meshheading:10331975-Gene Expression Regulation, Developmental, pubmed-meshheading:10331975-Heart, pubmed-meshheading:10331975-Heart Defects, Congenital, pubmed-meshheading:10331975-Heart Septal Defects, Atrial, pubmed-meshheading:10331975-Heart Septal Defects, Ventricular, pubmed-meshheading:10331975-Heart Ventricles, pubmed-meshheading:10331975-Homozygote, pubmed-meshheading:10331975-Male, pubmed-meshheading:10331975-Metalloendopeptidases, pubmed-meshheading:10331975-Metalloproteases, pubmed-meshheading:10331975-Mice, pubmed-meshheading:10331975-Mice, Inbred C57BL, pubmed-meshheading:10331975-Mice, Mutant Strains, pubmed-meshheading:10331975-Myocardium, pubmed-meshheading:10331975-Phenotype, pubmed-meshheading:10331975-Proteins, pubmed-meshheading:10331975-Recombination, Genetic, pubmed-meshheading:10331975-Tolloid-Like Metalloproteinases
pubmed:year
1999
pubmed:articleTitle
The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.
pubmed:affiliation
Department of Pathology and Laboratory Medicine and Cardiovascular Research Center, University of Wisconsin, Madison, WI 53706, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't