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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-7-21
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pubmed:abstractText |
The onset of differentiation-specific gene expression in skeletal muscle is coupled to permanent withdrawal from the cell cycle. The retinoblastoma tumor-suppressor protein (pRb) is a critical regulator of this process, required for both cell-cycle arrest in G0 phase and high-level expression of late muscle-differentiation markers. Although the cell-cycle defects that are seen in pRb-deficient myocytes can be explained by the well-described function of pRb as a negative regulator of the transition from G1 to S phase, it remains unclear how pRb positively affects late muscle-gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Creatine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Herpes Simplex Virus Protein Vmw65,
http://linkedlifedata.com/resource/pubmed/chemical/Mef2c protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/MyoD Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Myogenic Regulatory Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/myocyte-specific enhancer-binding...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
449-59
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10322110-Animals,
pubmed-meshheading:10322110-Binding Sites,
pubmed-meshheading:10322110-Cell Cycle,
pubmed-meshheading:10322110-Cell Differentiation,
pubmed-meshheading:10322110-Cell Nucleus,
pubmed-meshheading:10322110-Creatine Kinase,
pubmed-meshheading:10322110-DNA,
pubmed-meshheading:10322110-DNA-Binding Proteins,
pubmed-meshheading:10322110-G0 Phase,
pubmed-meshheading:10322110-Gene Expression Regulation,
pubmed-meshheading:10322110-Herpes Simplex Virus Protein Vmw65,
pubmed-meshheading:10322110-Mice,
pubmed-meshheading:10322110-Muscle, Skeletal,
pubmed-meshheading:10322110-MyoD Protein,
pubmed-meshheading:10322110-Myogenic Regulatory Factors,
pubmed-meshheading:10322110-Promoter Regions, Genetic,
pubmed-meshheading:10322110-Recombinant Fusion Proteins,
pubmed-meshheading:10322110-Retinoblastoma Protein,
pubmed-meshheading:10322110-Serine,
pubmed-meshheading:10322110-Transcription Factors,
pubmed-meshheading:10322110-Transcriptional Activation
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pubmed:year |
1999
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pubmed:articleTitle |
pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation.
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pubmed:affiliation |
Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School 240 Longwood Avenue, Boston, Massachusetts, 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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