. . . . . . . . . "10" . "1999-6-14" . "The mouse NK1.1 Ag originally defined as NK cell receptor (NKR)-P1C (CD161) mediates NK cell activation. Here, we show that another member of the mouse CD161 family, NKR-P1B, represents a novel NK1.1 Ag. In contrast to NKR-P1C, which functions as an activating receptor, NKR-P1B inhibits NK cell activation. Association of NKR-P1B with Src homology 2-containing protein tyrosine phosphatase-1 provides a molecular mechanism for this inhibition. The existence of these two NK1.1 Ags with opposite functions suggests a potential role for NKR-P1 molecules, such as those of the Ly-49 gene family, in regulating NK cell function." . "eng" . . "AIM" . . . . . . . . . . . . . . . . . "MEDLINE" . "May" . "0022-1767" . . . . . . . "Print" . "15" . "162" . "NLM" . "Y" . "5917-23" . "2008-11-21" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "1999" . "Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function." . "Departments ofImmunology and Anatomy and Cell Biology, University of Toronto, Toronto, Ontario, Canada." . "Journal Article" . "Research Support, Non-U.S. Gov't" .