Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-5-18
pubmed:abstractText
Insulin-like growth factor II (IGF-II) is a peptide growth factor that is homologous to both insulin-like growth factor I (IGF-I) and insulin and plays an important role in embryonic development and carcinogenesis. IGF-II is believed to mediate its cellular signaling via the transmembrane tyrosine kinase type 1 insulin-like growth factor receptor (IGF-I-R), which is also the receptor for IGF-I. Earlier studies with both cultured cells and transgenic mice, however, have suggested that in the embryo the insulin receptor (IR) may also be a receptor for IGF-II. In most cells and tissues, IR binds IGF-II with relatively low affinity. The IR is expressed in two isoforms (IR-A and IR-B) differing by 12 amino acids due to the alternative splicing of exon 11. In the present study we found that IR-A but not IR-B bound IGF-II with an affinity close to that of insulin. Moreover, IGF-II bound to IR-A with an affinity equal to that of IGF-II binding to the IGF-I-R. Activation of IR-A by insulin led primarily to metabolic effects, whereas activation of IR-A by IGF-II led primarily to mitogenic effects. These differences in the biological effects of IR-A when activated by either IGF-II or insulin were associated with differential recruitment and activation of intracellular substrates. IR-A was preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney and had a relatively increased proportion of isoform A. IR-A expression was also increased in several tumors including those of the breast and colon. These data indicate, therefore, that there are two receptors for IGF-II, both IGF-I-R and IR-A. Further, they suggest that interaction of IGF-II with IR-A may play a role both in fetal growth and cancer biology.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-10023720, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-1310798, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-1334404, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-1372573, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-1377676, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-1448116, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-1617668, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-1846534, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-2243127, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-2330056, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-2435731, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-2536310, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-2779582, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-2855493, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-2877871, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-2969892, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-3012553, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-3497713, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-6322765, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-7534307, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-7673254, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-7821729, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8248231, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8387505, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8402901, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8408055, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8440175, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8474457, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8486659, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8594980, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8635675, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8640796, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8670118, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8712068, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8725404, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8828504, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8866014, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8923458, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-8986409, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9108054, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9144243, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9165038, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9177406, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9205056, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9205065, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9248696, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9281335, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9291119, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9346957, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9502429, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9553088, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9589681, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9600271, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9609112, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9651379, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9671232, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9766674, http://linkedlifedata.com/resource/pubmed/commentcorrection/10207053-9771969
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent..., http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor II, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Mitogens, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin, http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3278-88
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
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