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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-4-22
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pubmed:abstractText |
The ability of cyclin-dependent kinases (CDKs) to promote cell proliferation is opposed by cyclin-dependent kinase inhibitors (CKIs), proteins that bind tightly to cyclin-CDK complexes and block the phosphorylation of exogenous substrates. Mice with targeted CKI gene deletions have only subtle proliferative abnormalities, however, and cells prepared from these mice seem remarkably normal when grown in vitro. One explanation may be the operation of compensatory pathways that control CDK activity and cell proliferation when normal pathways are inactivated. We have used mice lacking the CKIs p21(Cip1) and p27(Kip1) to investigate this issue, specifically with respect to CDK regulation by mitogens.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDC2-CDC28 Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/CDK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-73
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10074425-Animals,
pubmed-meshheading:10074425-CDC2-CDC28 Kinases,
pubmed-meshheading:10074425-Cell Cycle Proteins,
pubmed-meshheading:10074425-Cells, Cultured,
pubmed-meshheading:10074425-Cyclin-Dependent Kinase 2,
pubmed-meshheading:10074425-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:10074425-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:10074425-Cyclin-Dependent Kinases,
pubmed-meshheading:10074425-Cyclins,
pubmed-meshheading:10074425-Embryo, Mammalian,
pubmed-meshheading:10074425-Enzyme Inhibitors,
pubmed-meshheading:10074425-Fibroblasts,
pubmed-meshheading:10074425-Gene Deletion,
pubmed-meshheading:10074425-Humans,
pubmed-meshheading:10074425-Mice,
pubmed-meshheading:10074425-Mice, Knockout,
pubmed-meshheading:10074425-Microtubule-Associated Proteins,
pubmed-meshheading:10074425-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10074425-Recombinant Proteins,
pubmed-meshheading:10074425-Spleen,
pubmed-meshheading:10074425-T-Lymphocytes,
pubmed-meshheading:10074425-Transfection,
pubmed-meshheading:10074425-Tumor Suppressor Proteins
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pubmed:year |
1999
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pubmed:articleTitle |
A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells.
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pubmed:affiliation |
Cancer Biology Group Amgen Inc. Thousand Oaks California USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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