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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0026336,
umls-concept:C0085295,
umls-concept:C0185117,
umls-concept:C0205227,
umls-concept:C0333361,
umls-concept:C0542341,
umls-concept:C0851285,
umls-concept:C2003941,
umls-concept:C2350701,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
1999-3-11
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pubmed:abstractText |
In this study we have determined the role of endogenous interleukin (IL)-10 on leucocyte recruitment and production of the CC chemokine macrophage inflammatory protein-1alpha (MIP-1alpha) in a murine model of acute inflammation. Intraperitoneal injection of zymosan produced a dose-dependent cellular infiltration which was concomitant with MIP-1alpha release in the lavage fluids. Release of this chemokine had a functional role since treatment of mice with a specific anti-MIP-1alpha antibody reduced both neutrophil and monocyte accumulation into the peritoneal cavity. An unexpected increase in cell influx and MIP-1alpha production was measured following depletion of resident peritoneal macrophages, as achieved by a 3-day liposome treatment. A similar result was obtained when the zymosan peritonitis response was elicited in IL-10 knock-out mice. In summary we propose a functional cross talk between endogenous IL-10 and this CC chemokine during the host inflammatory response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
255
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
279-82
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10049699-Acute Disease,
pubmed-meshheading:10049699-Animals,
pubmed-meshheading:10049699-Cell Movement,
pubmed-meshheading:10049699-Chemokine CCL3,
pubmed-meshheading:10049699-Chemokine CCL4,
pubmed-meshheading:10049699-Disease Models, Animal,
pubmed-meshheading:10049699-Injections, Intraperitoneal,
pubmed-meshheading:10049699-Interleukin-10,
pubmed-meshheading:10049699-Leukocyte Count,
pubmed-meshheading:10049699-Macrophage Inflammatory Proteins,
pubmed-meshheading:10049699-Macrophages, Peritoneal,
pubmed-meshheading:10049699-Male,
pubmed-meshheading:10049699-Mice,
pubmed-meshheading:10049699-Mice, Inbred C57BL,
pubmed-meshheading:10049699-Mice, Knockout,
pubmed-meshheading:10049699-Monocytes,
pubmed-meshheading:10049699-Neutrophils,
pubmed-meshheading:10049699-Peritonitis,
pubmed-meshheading:10049699-Zymosan
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pubmed:year |
1999
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pubmed:articleTitle |
Regulation of macrophage inflammatory protein-1 alpha expression and function by endogenous interleukin-10 in a model of acute inflammation.
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pubmed:affiliation |
Department of Biochemical Pharmacology, The William Harvey Research Institute, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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