Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-3-25
pubmed:abstractText
Pten/Mmac1+/- heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was detected in neoplasms of the thymus and liver. Surprisingly, tumors of the gastrointestinal epithelium developed in association with gut lymphoid tissue. Tumors of the endometrium, thyroid, prostate, and liver were not associated with lymphoid tissue and appeared to be highly mitotic. In addition, these mice have nonneoplastic hyperplasia of lymph nodes that was caused by an inherited defect in apoptosis detected in B cells and macrophages. Examination of peripheral lymphoid tissue including lymphoid aggregates associated with polyps revealed that the normal organization of B and T cells was disrupted in heterozygous animals. Taken together, these data suggest that PTEN is a regulator of apoptosis and proliferation that behaves as a "landscaper" tumor suppressor in the gut and a "gatekeeper" tumor suppressor in other organs.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-1350108, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-1484317, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-6496844, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-7550343, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-7581453, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-7639335, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-7989752, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-8652050, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9072974, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9090379, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9140396, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9171827, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9177527, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9187108, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9241266, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9252325, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9286463, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9288766, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9288767, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9307275, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9326929, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9331071, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9331072, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9354433, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9356475, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9371490, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9393738, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9434957, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9467011, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9533551, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9593664, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9616081, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9671321, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9697695, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9753318, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9778245, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9799734, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9799739, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9811831, http://linkedlifedata.com/resource/pubmed/commentcorrection/9990064-9865719
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1563-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:9990064-Animals, pubmed-meshheading:9990064-Animals, Newborn, pubmed-meshheading:9990064-Crosses, Genetic, pubmed-meshheading:9990064-Embryonic and Fetal Development, pubmed-meshheading:9990064-Female, pubmed-meshheading:9990064-Gene Expression Regulation, Developmental, pubmed-meshheading:9990064-Genes, Tumor Suppressor, pubmed-meshheading:9990064-Genetic Predisposition to Disease, pubmed-meshheading:9990064-Genotype, pubmed-meshheading:9990064-Hamartoma Syndrome, Multiple, pubmed-meshheading:9990064-Heterozygote, pubmed-meshheading:9990064-Male, pubmed-meshheading:9990064-Mice, pubmed-meshheading:9990064-Mice, Knockout, pubmed-meshheading:9990064-Neoplasms, Experimental, pubmed-meshheading:9990064-PTEN Phosphohydrolase, pubmed-meshheading:9990064-Phosphoric Monoester Hydrolases, pubmed-meshheading:9990064-Pregnancy, pubmed-meshheading:9990064-Restriction Mapping, pubmed-meshheading:9990064-Tumor Suppressor Proteins
pubmed:year
1999
pubmed:articleTitle
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems.
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