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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1999-2-25
|
pubmed:abstractText |
We recently identified and cloned novel breast cancer-specific gene BCSG1 by direct differential cDNA sequencing. BCSG1 has a great sequence homology with the Alzheimer's disease related neural protein synuclein (SNC); thus, it was also named SNC-gamma. Overexpression of SNC-gamma in breast cancer cells leads to a significant increase in motility and invasiveness in vitro and a profound augmentation of metastasis in vivo. Our data suggest that this member of the neural protein SNCs might have important functions outside the central nervous system and may play a role in breast cancer progression.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0008-5472
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
59
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
742-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9973226-Animals,
pubmed-meshheading:9973226-Breast Neoplasms,
pubmed-meshheading:9973226-Cell Division,
pubmed-meshheading:9973226-Cell Movement,
pubmed-meshheading:9973226-Humans,
pubmed-meshheading:9973226-Mice,
pubmed-meshheading:9973226-Mice, Nude,
pubmed-meshheading:9973226-Neoplasm Invasiveness,
pubmed-meshheading:9973226-Neoplasm Metastasis,
pubmed-meshheading:9973226-Nerve Tissue Proteins,
pubmed-meshheading:9973226-Stimulation, Chemical,
pubmed-meshheading:9973226-Synucleins,
pubmed-meshheading:9973226-Transfection
|
pubmed:year |
1999
|
pubmed:articleTitle |
Stimulation of breast cancer invasion and metastasis by synuclein gamma.
|
pubmed:affiliation |
Department of Pediatrics, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|