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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-3-18
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pubmed:abstractText |
Hemodynamic alterations have been implicated as major stimuli for the development of intimal hyperplasia in vein grafts that are implanted in the arterial circulation. Tyrosine kinase is known to mediate cell signaling. However, its role with in vivo mechanotransduction is not yet well defined. We used a novel bioprosthetic collagen tube to provide an external support to vein grafts and examined the subsequent changes in hemodynamics, tyrosine kinase signaling, wall remodeling, and vasomotor function.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0741-5214
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
334-44
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9950991-Animals,
pubmed-meshheading:9950991-Biomechanics,
pubmed-meshheading:9950991-Blood Flow Velocity,
pubmed-meshheading:9950991-Blotting, Western,
pubmed-meshheading:9950991-Carotid Arteries,
pubmed-meshheading:9950991-Dose-Response Relationship, Drug,
pubmed-meshheading:9950991-Hemodynamics,
pubmed-meshheading:9950991-Hyperplasia,
pubmed-meshheading:9950991-Male,
pubmed-meshheading:9950991-Phosphorylation,
pubmed-meshheading:9950991-Protein-Tyrosine Kinases,
pubmed-meshheading:9950991-Rabbits,
pubmed-meshheading:9950991-Tunica Intima,
pubmed-meshheading:9950991-Tunica Media,
pubmed-meshheading:9950991-Vasoconstrictor Agents,
pubmed-meshheading:9950991-Vasodilator Agents,
pubmed-meshheading:9950991-Veins
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pubmed:year |
1999
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pubmed:articleTitle |
Alterations in wall tension and shear stress modulate tyrosine kinase signaling and wall remodeling in experimental vein grafts.
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pubmed:affiliation |
Vascular Biology and Atherosclerosis Research Laboratory, Departments of Surgery, Duke University Medical Center, Durham, NC, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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