Linked Life Data

9923410

Source:http://linkedlifedata.com/resource/pubmed/id/9923410

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-4-7
pubmed:abstractText
We explored the relationship between individual human leukocyte antigens (HLAs) and the risk of acute graft-vs.-host disease (GVHD) after allogeneic marrow transplantation from HLA-identical siblings. If the repertoire of polymorphic peptides encoded by minor histocompatibility loci is limited such that certain major histocompatibility complex molecules might not present any peptides that cause GVHD, then certain HLA alleles should be associated with a relatively reduced risk of GVHD and others should be associated with a relatively increased risk. Contrary to results reported in previous studies, we found no convincing evidence for associations between HLA antigens and risk of acute GVHD after HLA-identical marrow transplantation. These results are consistent with the hypothesis that the variety of minor histocompatibility antigens is not constrained by the repertoire of peptides collectively encoded by minor histocompatibility loci.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1083-8791
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
128-33
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
HLAs and risk of acute graft-vs.-host disease after marrow transplantation from an HLA-identical sibling.
pubmed:affiliation
Fred Hutchinson Cancer Research Center and the Department of Medicine, University of Washington, Seattle 98109-1024, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.