Linked Life Data

989707

Source:http://linkedlifedata.com/resource/pubmed/id/989707

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1976-12-1
pubmed:abstractText
Methoxyflurane, at the moment the most potent inhalation anaesthetic, was examined in respect of its surfactant irritating properties in the rabbit. After a five hour anaesthesia with this compound there was, compared with a control group of animals which underwent only mechanical ventilation with room air for the same period, a significant decline of the compliance quotient from 2.99 to 2.55, indicating a relevant impairment of alveolar lining surfactant. A concomitant fall of arterial PaO2 from 84.8 to 71.3 mm Hg showed the resulting deterioration of respiratory function. Postanaesthetic preparations of these lungs examined using the Wilhelmy balance exhibited a significant fall of the stability index from 1.73 to 1.25, though hysteresis remained unaffected. Lung histology showed interstitial edema and patchy atelectasis, features which are found also in the early stages of post-traumatic pulmonary insufficiency. On this basis we recommend that methoxyflurane is not used in patients with impaired surfactant activity as such is found after severe traumatisation, head injury or in special preexisting pulmonary diseases. If this anesthetic is given to healthy individuals, the ventilatory pattern should include periodic sighs and prophylactic PEEP.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-2417
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
431-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
[The influence of methoxyflurane (penthrane) on surface activity of the lung (author's transl)].
pubmed:publicationType
Journal Article, English Abstract