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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1999-2-12
|
| pubmed:abstractText |
Leukotriene B4 (LTB4), one of the metabolites of arachidonic acid via 5-lipoxygenase (5-LO), plays important role in some inflammatory diseases as one of the most potent chemotaxis factor. A radio-ligand binding assay was set up and the characteristics of LTB4 receptor on guinea-pig splenocytes membrane were studied. At 25 degrees C, the Kd was found to be 1.55 x 10(-9) mol.L-1 and the Bmax was 2.59 x 10(-13) mol.mg-1 protein. The assay established was evaluated by nordihydroguaiaretic acid (NDGA) as positive control.
|
| pubmed:language |
chi
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0513-4870
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
875-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9863260-Animals,
pubmed-meshheading:9863260-Binding, Competitive,
pubmed-meshheading:9863260-Cell Membrane,
pubmed-meshheading:9863260-Female,
pubmed-meshheading:9863260-Guinea Pigs,
pubmed-meshheading:9863260-Radioligand Assay,
pubmed-meshheading:9863260-Receptors, Leukotriene B4,
pubmed-meshheading:9863260-Spleen
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
[Studies on the characteristics of leukotriene B4 receptor with radio-ligand binding assay].
|
| pubmed:affiliation |
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
|
| pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|